Anaesthetic drugs

Question 1

Thiopental

Answer 1

Thiobarbituate
IV induction
3-7 mg/kg
1/2 life: 5-10 mins

Question 2

Ketamine

Answer 2

Phencyclidine derivative
IV induction 1-2mg/kg
anaesthesia 0.2-0.5mg/kg

dissociative anaesthetic

Increases adrenaline and noradrenaline output
Bronchodilation

Question 3

Midazolam

Answer 3

benzodiazapine
sedation and anxiolysis
Works near gaba recept
0.02-0.1 mg/kg

Question 4

Glycopyrolate

Answer 4

anti-cholinergic (muscarinic)
Used to increased HR
(usually during sedation)
~200mcg

Question 5

Atropine

Answer 5

anti-cholinergic (muscarinic)
blocks vagus nerve
3mg

Question 6

Adrenaline

Answer 6

Alpha + beta agonist 
catecholamine 
IV infusion 
0.01-0.1 mcg/kg
Vasopressor/inotrope

Question 7

Ephedrine

Answer 7

indirect sympathomemetic

Increased HR, CO, BP, coronary blood flow

Question 8

phenyephirine

Answer 8

alpha 1 agonist
Vasoconstriction
short half life

Question 9

Metaraminol

Answer 9

sympathomemetic
vasoconstriction
Increases SVR, BP, RR

Question 10

Oxytocin

Answer 10

synthetic posterior pituitary hormone

Increases uterine contractions

Question 11

Proprofol

Answer 11

IV induction agent 
rapid onset 
1.5-2.5mg/kg 
Decreased BP, SV, CO, HR
Decreases laryngeal reflex 
Bronchodilator 
antiemetic

Question 12

Non-depolarising muscle blockers

Answer 12

Rocuronium
Vecuronium
Mivacurium
cistaracurium
atracurium

Question 13

Suxamethonium

Answer 13

Depolarising muscle relaxant
Rapid onset
fasiculations before flaccid paralysis

Question 14

Neostigmine

Answer 14

Reversal agent

Usually used with glycopyronim

Question 15

Ondansetron

Answer 15

5HT3 antagonist

Question 16

Remifentanyl

Answer 16

super/ultra fast short acting opiod
infusion
short acting

Question 17

Fentanyl

Answer 17

Short acting potent opioid

Question 18

Alfentail

Answer 18

very short acting, less potent opioid

Question 19

morphine

Answer 19

longish acting opioid
3-5 hours
0-10mg

Question 20

levobupivicaine

Answer 20

long acting amide local anesthetic

Question 21

lidocaine

Answer 21

short acting local anaesthetic

Intra cellular Na blocker

Question 22

tranexamic acid

Answer 22

antifibrinolytic - stops clot breakdown

Trauma/ortho

Question 23

Parecoxib

Answer 23

NSAID
COX 2 selective
Analgesic