Anaesthesia Flashcards
What type of physiological changes are expected with liver disease which may have an impact on anaesthesia and surgery?
- Altered pharmacokinetics of anaesthetic drugs
- Altered glucose metabolism
- Reduced albumin production
- Increased bleeding tendencies
- Jaundice
- Hepatomegaly
What features of gastrointestinal disease should be taken into account during anaesthesia?
- Disturbances in fluid, electrolytes, acid-base balance, and protein levels
- Hypovitaminosis, weight loss, and emaciation
Why should morphine and alpha2-agonists be avoided in patients with gastrointestinal disease?
- These drugs induce nausea and vomiting
What modulates cerebral vascular resistance (CVR)?
Blood-gas values, especially PaCO2
What is the cerebral perfusion pressure?
- Difference between carotid arterial blood pressure and jugular venous pressure
- Cerebral perfusion pressure (CPP) is defined as the difference between the force driving blood into the brain (mean arterial pressure [MAP]) and the force resisting movement of blood into the brain (intracranial pressure [ICP] or central venous pressure [CVP], whichever is the highest).
What is the Monro-Kellie Hypothesis?
Any increase in volume in either of cellular component, ventricles, and blood vessels of the brain has to have a reciprocal decrease in the other two, or the intracranial pressure will rise
What is the cerebral central venous pressure (CVP)?
Pressure that resists movement of blood into the brain
Describe the physiological changes severe hyperventilation will cause in the brain.
Severe hyperventilation decreases CO2 pressure. A decrease in PaCO2 will cause vasoconstriction of cerebral blood vessels. Thus, a reduction in PaCO2 by hyperventilating can cause a rapid decrease in cerebral blood flow and intracranial pressure.
Describe the physiological changes severe hypoventilation will cause in the brain.
Severe hypoventilation will cause an increase in PaCO2 and will result vasodilation of cerebral vessels and increase in cerebral blood flow and intracranial pressure
How is cerebral blood flow calculated?
[Cerebral perfusion pressure]/[cerebral vascular resistance]
What are some options for treating intracranial hypertension?
- Minimize central venous pressure
- Modest hyperventilation
- Use of diuretics
- Use of steroidal anti-inflammatories
- Use of cytoneuroprotectives
- Induction of hypothemia
- Craniotomy
What are some methods to minimize central venous pressure in the brain perioperatively?
- Use of head-up position
- Avoidance of fluid overload
- Avoidance of coughing and gagging (causes the vessels in the head to expand)
What is Mannitol?
- Osmotic diuretic
Name a steroidal anti-inflammatory.
Methylprednisolone
How can occular immobility be achieved for occular surgery?
- Stay sutures
- Retrobulbar block
- Deep anaesthesia
- Neuromuscular block