Anaemia

Question 1

where is iron absorbed

Answer 1

duodenum

Question 2

how is iron transported in the blood

Answer 2

bound to transferrin

Question 3

what does ferritin reflect

Answer 3

iron stores

Question 4

what type of anaemia does iron deficiency cause

Answer 4

microcytic anaemia (low MCV)

Question 5

most common cause of iron deficiency anaemia

Answer 5

blood loss

• GI tract
• menstruation in pre-menopausal women

Question 6

what does a high total iron binding capacity reflect

Answer 6

low iron stores

Question 7

investigation for iron deficiency anaemia

Answer 7

GI scope

Question 8

pencil poikilocytes on blood film

Answer 8

iron deficiency anaemia

Question 9

what is pernicious anaemia

Answer 9

autoimmune condition where antibodies form against parietal cells
- cause of B12 deficiency

Question 10

where is vit B12 absorbed

Answer 10

ilium

Question 11

what is needed for B12 absorption

Answer 11

intrinsic factor from gastric parietal cells

Question 12

antibody in pernicious anaemia

Answer 12

intrinsic factor antibody

Question 13

what neurological symptoms can B12 deficiency cause

Answer 13

peripheral neuropathy

mood/cognitive changes

Question 14

treatment of pernicious anaemia

Answer 14

hydroxycobalamin 3

Question 15

treatment of dietary deficiency B12

Answer 15

Cyanocobalamin

Question 16

what deficiency do you need to correct first- folate or B12?

Answer 16

correct B12 before folate to prevent subacute degeneration of spinal cord

Question 17

vit B12 and folate deficiency cause what kind of anaemia

Answer 17

macrocytic megaloblastic