Anaemia Flashcards

1
Q

What is Anaemia?

A

Decrease in red cell mass to a level that is insufficient for tissue respiration

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2
Q

Anaemia is also a decrease in the —— to a level that has become insufficient to tissue respiration

A

Oxygen carrying capacity of the blood

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3
Q

The protein that Carrie’s oxygen in the blood is?

A

Haemoglobin

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4
Q

Hb is packaged in the —— of a red cell

A

Cytoplasm

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5
Q

Decrease in Hb concentration appears to vary according to?

A

Age and sex

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6
Q

At what conc does oxygen delivery to the tissue become impaired in males?

A

<13g/dl

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7
Q

At what conc does oxygen delivery to the tissue become impaired in females

A

<12g/dl

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8
Q

At what conc does oxygen delivery to the tissue become impaired in children 6-14years?

A

<12g/dl

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9
Q

At what conc does oxygen delivery to the tissue become impaired in children aged 30days old - 6 years of age?

A

<11g/dl

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10
Q

At what conc does oxygen delivery to the tissue become impaired for neonates(age 0-30days)

A

<13.5g/dl

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11
Q

What is oxygen carrying capacity?

A

It is the total amount of oxygen the blood is able to deliver to the tissues per minute

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12
Q

The protein that delivers oxygen to the tissues is?

A

Haemoglobin

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13
Q

What is oxygen tension of blood?

A

The amount of oxygen present in 100ml of blood

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14
Q

What is the normal oxygen tension of blood?

A

20ml of oxygen per 100ml of blood

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15
Q

You only get 20ml of oxygen per 100ml of blood at what concentration of Haemoglobin?

A

15g/dl

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16
Q

With decrease in Hb concentration Oxygen tension increases. T/F

A

False

17
Q

When is the corresponding partial pressure of Oxygen in the blood when the volume of oxygen is 20mls?

A

100mmHg

18
Q

When oxygen has a volume of 15ml what is the partial pressure then?

A

40mmHg

19
Q

What is the arterial Oxygen tension and Venous oxygen tension when the Hb conc is 15g/dl

A

Arterial-20mls
Venous-15mls

20
Q

What is the pressure head of Oxygen tension in the venous blood?

A

40mmHg

21
Q

Arteriovenous oxygen difference is?

A

5ml

22
Q

Every 100ml of blood will give —— ml of oxygen to the tissue and retain —— ml

A

5ml
15ml

23
Q

An individual with a Hb conc of 10g/dl has a Volume of oxygen and partial pressure as?

A

13.4ml and partial pressure <40mmHg

24
Q

What are the 4 physiologic adaptations to Anaemia?

A

1)Modulation of Hb oxygen affinity
2)Cardiovascular adaptive mechanism/compensatory mechanism
3)Redistribution of blood flow from less sensitive oxygen tissues to more sensitive oxygen tissues
4)Mexhanisms to widen the narrowed arteriovenous oxygen difference by bringing down the venous oxygen tension of the blood to a level far below 15ml

25
Q

Hb is an irreversible oxygen carrier. T/F

A

False. It’s reversible

26
Q

Abnormal Hb with excessive avidity for Oxygen are called?

A

HIGH- OXYGEN AFFINITY Hb

27
Q

In Anemic conditions, the line of oxygen by the normal Haemoglobin is increased. T/F

A

False