Anaemia Flashcards
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Patient counselling:
- Not everyone experiences s.e. however these are some - constipation, diarrhoea, GI disturbances, nausea
- Can colour stool brown
- Do not take NSAID?
- Increase iron levels
- Iron is absorbed in the small intestine (duodenum and first part of the jejunum). This means that enteric-coated iron tablets may not work as well.
- If you take antacids, you should take iron tablets two hours before or four hours after the antacid.
- Vitamin C (ascorbic acid) improves iron absorption, and some doctors recommend that you take 250 mg of vitamin C with iron tablets.
A 26-year-old female has been diagnosed with microcytic anaemia.
Which one of the following nutritional deficiencies is most likely to be contributing to this diagnosis?
Select one:
A. Folate deficiency
B. Iron deficiency Correct
C. Vitamin B6 deficiency
D. Vitamin B12 deficiency
E. Vitamin D deficiency
Microcytic Anaemia (low MCV) most commonly due to iron deficiency.
Reference: https://bestpractice.bmj.com/topics/en-gb/93/aetiology
The correct answer is: Iron deficiency
When a patient has an overload of this substance, deferasirox should be administered to the patient.
Indicated for the treatment of chronic iron overload when desferrioxamine is contraindicated or inadequate (with non-transfusion-dependent thalassaemia syndromes).
How should I treat a person with folate deficiency anaemia?
Prescribe oral folic acid 5 mg daily — in most people, treatment will be required for 4 months. However, folic acid may need to be taken for longer (sometimes for life) if the underlying cause of deficiency is persistent.
Check vitamin B12 levels in all people before starting folic acid — treatment can improve wellbeing, mask an underlying B12 deficiency, and allow the neurological disease to develop.
Give dietary advice about foods that are a good source of folic acid — good sources of folate include:
- Asparagus.
- Broccoli.
- Brown rice.
- Brussels sprouts.
- Chickpeas.
- Peas.
Why should iron-deficiency anaemia be managed preoperatively?
- Predictor of postoperative outcome - increased perioperative blood transfusion and postoperative morbidity and mortality
- iron deficiency anaemia: Haemoglobin
- <130 g/L (13 g/dL) in men older than age 15 years,
- <120 g/L (12 g/dL) in nonpregnant women older than age 15 years,
- <110 g/L (11 g/dL) in pregnant women
- Should start 3 weeks before surgery
What are the adverse side effects of iron tablets?
Constipation
Nausea Vomiting
A 74-year-old man with stage IV chronic kidney disease secondary to type II diabetes mellitus is admitted to the acute medical assessment ward with symptoms of breathlessness and reduced exercise tolerance. He is otherwise systemically well. His blood results are as follows:
- Haemoglobin 80 g/l
- Mean Corpuscular Volume 90 fl
- Mean Corpuscular Haemoglobin 30 pg
- Urea 17 mmol/l
- Creatinine300 µmol/l
- eGFR8 ml/min/1.73m2
Given the likely cause of this patient’s anaemia, which of the following compounds is the patient most likely to be deficient of?
- Vitamin B1
- Ferritin
- Folate
- Erythropoietin
- T3 / T4
In many cases of advanced renal failure, the kidneys’ ability to produce erythropoietin is reduced, leading to anaemia of chronic disease. There are several factors involved in renal anaemia, however a lack of erythropoietin is the most significant contributor.
Typically this deficiency manifests as a normochromic, normocytic anaemia, as seen in this patient’s blood results.
In Vitamin B12/Folate deficiency and some cases of hypo/hyperthyroidism, a macrocytic anaemia is seen. Low ferritin levels will lead to a microcytic anaemia.
A 71-year-old male attends renal clinic for a review of his chronic kidney disease (CKD. He has type 2 diabetes and CKD stage 4. His latest eGFR is 21ml/min/1.73m². He explains that over the past 1 month, he has been feeling fatigued and has noticed shortness of breath on exertion. Review of his blood tests show:
- Hb91 g/LMale: (135-180)
- Ferritin16 ng/mL(20 - 230)
- Vitamin B12342 ng/L(200 - 900)
- Folate3.8 nmol/L(> 3.0)
He denies any change in bowel habits, abdominal pain or rectal bleeding.
What is the most appropriate initial action?
- Prescribe an erythropoiesis-stimulating agent (ESA)
- Prescribe ferrous sulphate
- Prescribe folic acid
- Reassurance and monitoring
- Prescribe vitamin B12 injections
The most appropriate initial action, in this case, is to prescribe ferrous sulphate. This patient has an iron deficiency anaemia and therefore should be given iron replacement. Iron deficiency should be corrected before starting erythropoiesis-stimulating agents (ESA).
Prescribe an ESA is not an appropriate first-line management option as this patient has iron deficiency and this should be corrected first.
Prescribe folic acid is inappropriate as this patient has normal folate levels.
Reassurance and monitoring is an incorrect answer as it does not address this patient’s symptomatic anaemia.
Prescribe vitamin B12 injections is inappropriate as his vitamin B12 levels are normal therefore this is not the cause of his anaemia.
A 71-year-old male with a background of stage 5 chronic kidney disease presents to the hospital with increasing fatigue and breathlessness. He undergoes haemodialysis regularly, 3 times a week.
Lab results are as follows:
- Hb102g/LMale: (135-180)
- Female: (115 - 160)
- MCV83 fl(82 - 100)
- eGFR14 ml/min/1.73m(>90)
- Ferritin11 ng/mL(20 - 230)
- Transferrin saturation12%(20 - 50)
Which of the following is the most appropriate initial management option?
- Erythropoietin stimulating agent
- Folate supplements
- IM cyanocobalamin
- IV iron infusion
- Venesection
Anaemia is a common complication of chronic kidney disease. It can be due to impaired erythropoietin (EPO) production from the kidneys. EPO stimulates erythropoiesis in the bone marrow. Erythropoietin stimulating agents (ESA) could be given if the patient had a normal iron level, but because iron is required to create new red blood cells, the haemoglobin concentration will not increase by much if the patient is iron deficient. Therefore, correcting the iron deficiency before giving an ESA would be more appropriate in this scenario. IV iron infusion is used instead of oral iron as it has better bioavailability and rapid efficacy.
Folate supplements would treat folate deficiency, which causes a macrocytic anaemia. Folate deficiency is commonly caused by malnutrition, inflammatory bowel disease, coeliac disease and can also be caused by medication such as methotrexate.
Cyanocobalamin supplementation would be the treatment for B12 deficiency, but this patient has a normocytic anaemia, so we would not suspect B12 (or folate) deficiency. B12 deficiency is commonly caused by atrophic gastritis, Crohn’s disease or malnutrition.
Venesection is incorrect as this is the treatment for iron overload disorders such as haemochromatosis.
A 71-year-old woman with a background of type II diabetes and chronic kidney disease (CKD) is reviewed by her GP. Her recent blood tests have shown that her haemoglobin level and estimated glomerular filtration rate (eGFR) has fallen gradually over the last year. Her blood tests can be found below.
- Hb94g/LMale: (135-180)
- Female: (115 - 160)
- Platelets268* 109/L(150 - 400)
- WBC5.1* 109/L(4.0 - 11.0)
- MCV76(80-100fL)
- Na+139mmol/L(135 - 145)
- K+3.9mmol/L(3.5 - 5.0)
- Urea5.9mmol/L(2.0 - 7.0)
- Creatinine118µmol/L(55 - 120)
- eGFR31ml/min/1.73m2(>89ml/min/1.73m2)
What would be the next appropriate management in view of her background of CKD?
- Check iron status
- Refer for blood transfusion
- Refer for dialysis
- Refer to commence erythropoietin (EPO)
- Urgently refer to the renal team
In a patient with suspected anaemia of chronic disease secondary to CKD, iron status should be checked prior to commencing EPO
If anaemia is present, arrange tests to exclude other causes of anaemia. Iron deficiency should be done first before considering the need to refer for erythropoietin (EPO). Renal anaemia should only be diagnosed after exclusion of other causes including iron deficiency, folate or B12 deficiency, haemolysis. Renal anaemia is unusual prior to CKD3b but if suspected, nephrology advice would be appropriate.
Referring for a blood transfusion won’t be necessary at this point since we have not excluded other causes for this low Hb. It is also usually not given until the patient’s haemoglobin count falls below 70g/l in a stable scenario where there is no acute haemorrhage or rapid correction of anaemia required.
Referral for dialysis is not appropriate at this point and is not indicated for the treatment of anaemia.
Referral to commence EPO can be considered once other causes are excluded e.g. iron-deficiency anaemia as per NICE guidance.
This scenario can be managed initially in a primary care setting and an urgent referral to the renal team won’t be necessary at this point.
A 41-year-old man with a background in polycystic kidney disease is reviewed in the clinic. He has been feeling increasingly fatigued over the past few months and cannot do his usual workout at the gym without becoming very breathless and tired. His blood tests are shown below:
- Hb84 g/LMale: (135-180)
- Female: (115 - 160)
- Platelets214 * 109/L(150 - 400)
- WBC5.6 * 109/L(4.0 - 11.0)
- Urea9.9 mmol/L(2.0 - 7.0)
- Creatinine301 µmol/L(55 - 120)
- Ferritin14 ng/mL(20 - 230)
- Vitamin B12368 ng/L(200 - 900)
- Folate3.2 nmol/L(> 3.0)
What is the most appropriate next step in his management?
- Arrange a packed red cell transfusion
- Start high-dose folate replacement
- Start oral iron replacement
- Start treatment with erythropoietin
- Start hydroxycobalamin replacement
Anaemia in CKD: correct iron deficiency before starting erythropoiesis-stimulating agents
Chronic kidney disease (CKD) is a common cause of anaemia due to several factors but most significantly the loss of the kidney’s production of erythropoietin. Erythropoietin is a cytokine responsible for inducing bone marrow production of erythrocytes (red blood cells). Recombinant erythropoietin can be given to treat CKD-associated anaemia but other factors should be corrected first before giving it. The blood results here indicate low ferritin, suggesting the need for iron supplementation. CKD can cause poor iron absorption and result in a need for supplementation, including regular intravenous infusions for patients receiving dialysis.
A transfusion would be inappropriate at present as his haemoglobin is still above 80 g/L and there is a reversible cause of his anaemia (iron deficiency).
Folate replacement is not required as his folate levels are replete.
Erythropoietin treatment would only be indicated if he remained symptomatically anaemic despite adequate iron replacement.
Hydroxycobalamin is the chemical name for vitamin B12. His vitamin B12 levels are replete so this is not indicated.
A 31-year-old gentleman with known epilepsy, depression and type 1 diabetes presents to his GP with a 1-week history of fatigue. He also says his gums have sometimes bled when he brushes his teeth. The GP requests some blood tests, which show the following:
- Haemoglobin92 g/L
- Mean Cell Volume92 fL
- White Cell Count (WCC)1.9 x 10 9 /L
- Platelet count29 x 10 9 /L
Which drug is most likely to explain the patient’s symptoms and blood test results?
- Phenytoin
- Sodium valproate
- Lamotrigine
- Sertraline
- Insulin
Phenytoin is a cause of aplastic anaemia
The blood tests show a normocytic anaemia, leukopenia and thrombocytopenia, which is the definition of aplastic anaemia. This is corroborated by the patient’s symptoms, which are highly suggestive of bone marrow failure.
Of all the medications he is likely to be taking due to his past medical history, only phenytoin is known to cause this. Note: sodium valproate can cause anaemia and thrombocytopenia but does not cause leukopenia.
Doctors at any level of training must be aware of the severe side-effects (like aplastic anaemia) for commonly used drugs, such as phenytoin. This is because not only does the aplastic anaemia need to be treated, but the offending drug must be stopped; this information must also be added to the patient’s medical notes so it is never prescribed again.
Other important drug causes of aplastic anaemia are cytotoxics, chloramphenicol, and sulphonamides.
A 62-year-old female presents to her general practitioner with a 2-month history of fatigue and poor concentration. She finds herself getting shortness of breath when walking to the shop, which previously did not cause her any issues. On examination, she is noted to be pale, cardiorespiratory and neurological examination is unremarkable. She has blood tests sent which show:
- Hb102 g/LMale: (135-180)
- Female: (115 - 160)
- Platelets161* 109/L(150 - 400)
- WBC4.0 * 109/L(4.0 - 11.0)
- Blood filmhypersegmented polymorphs
- Vitamin B12120 ng/L(>200)
- Folate1 ng/mL(2-10)
What is the most appropriate management (out of those listed) for this patient?
- Urgent referral to haematology
- Urgent referral to hospital for CT head
- B12 replacement - intramuscular replacement
- B12 replacement - oral replacement
- Folate replacement intramuscularly prior to B12 replacement
This patient has vitamin B12 and folate deficiency.
Symptoms: fatigue, poor concentration, and pallor are common
Bloods: her blood tests confirm this picture (anaemia, low B12, low folate, and hypersegmented polymorphs on blood film). There may also be thrombocytopenia in these patients - this is due to vitamin B12 acting as a co-factor during the synthesis phase of the cells in the bone marrow.
Examination: although her neurological examination is unremarkable, patients may present with peripheral neuropathy and ataxia.
This patient does not warrant urgent referral as she does not have any neurological symptoms and is not pregnant. NICE guidelines advise urgent referral if the patient has loss of cutaneous sensation, muscle weakness, optic neuropathy, psychiatric disturbance, symmetrical neuropathy, or urinary or faecal incontinence.
Referral to haematology should be considered also if the patient has a suspected haematological malignancy or blood disorder, the patient fails to respond to treatment, or mean cell volume is persistently > 105 femtolitres. Referral to gastroenterology should be made if the patient is suspected to have a malabsorption syndrome, gastric cancer, or has pernicious anaemia with GI symptoms.
The patient does not fulfil criteria for CT head and, as such, this answer is incorrect.
The recommendation of IM over oral replacement of B12 is outlined in the NICE guidelines. Some randomised control trials point to IM replacement being superior to oral and this is still the preferred route of administration as per guidelines.
Vitamin B12 replacement should always occur prior to folate replacement as folate replacement prior to B12 can precipitate subacute combined degeneration of the spinal cord.
A 72-year-old woman is brought to surgery with confusion and pallor. Her daughter reports that she has been getting more confused and tired for the past three months. Blood tests are reported as follows:
- Hb8.9 g/dl
- MCV125 fl
- Plt148 * 109/l
- WBC4.4 * 109/l
In light of the macrocytic anaemia some further tests are ordered:
- Intrinsic factor antibodies Negative
- Vitamin B1294 ng/l (200-900 ng/l)
- Folic acid1.1 nmol/l (> 3.0 nmol/l)
What is the most appropriate management?
- Perform an ECG immediately
- Oral folic acid + start Intramuscular vitamin B12 when folic acid levels are normal
- Intramuscular vitamin B12 + start oral folic acid when vitamin B12 levels are normal
- Refer to the local alcohol dependency services
- Admit for blood transfusion
Intramuscular vitamin B12 + start oral folic acid when vitamin B12 levels are normal.
It is important in a patient who is also deficient in both vitamin B12 and folic acid to treat the B12 deficiency first to avoid precipitating subacute combined degeneration of the cord. Consideration in this case should also be given to secondary care referral to identify the underlying cause
A 66-year-old man presents with a 3-month history of fatigue. He has hypertension for which he is on lisinopril, amlodipine, and indapamide, which he says he takes every day. There have been no recent changes to his medications or diet and he takes no other prescribed or over the counter medications.
Blood tests are performed and all are within normal ranges apart from full blood count which is as follows:
- Hb91 g/LMale: (135-180) Female: (115 - 160)
- Platelets344 * 109/L(150 - 400)
- WBC7.6 * 109/L(4.0 - 11.0)
- Red cell count2.9 * 109/L(1.0 - 3.5)
- MCV71 fL(82-100)
What is the most appropriate next step?
- Further blood tests for serum ferritin and total iron-binding capacity
- Recommend an iron-rich diet
- Tissue transglutaminase antibody blood test
- Oral ferrous sulfate for 3 months
- Urgent colorectal pathway referral
Patients over the age of 60 who present with iron deficiency anaemia should be investigated for colorectal cancer
The blood results show an iron deficiency anaemia. In patients over the age of 60, iron deficiency anaemia is a criterion for urgent referral (i.e. within 2 weeks) to colorectal services for investigation for colorectal cancer.
In a GP setting, a faecal immunochemical test (FIT) may be performed, but the urgent referral would still be made at the same time.
Colorectal cancer is the third most common type of cancer in the UK and can present with a change in bowel habit or blood in the stool, but can also be asymptomatic as the blood in the stool may not be visible.
- Further blood tests are not the most important next step here, as it is important to first rule out cancer here.
- Recommending an iron-rich diet could be a treatment option if the iron deficiency anaemia is a result of inadequate iron intake, but the cause has not yet been established and this needs to be done first.
- Tissue transglutaminase antibody blood test is the investigation of choice for coeliac disease, which is a potential cause of iron deficiency anaemia. However, the lack of other symptoms makes this less likely, and colorectal cancer is the more important diagnosis to rule out first.
- Oral ferrous sulfate for 3 months is a potential treatment option for iron deficiency anaemia, but it is important to first establish the cause, so this is the wrong answer.