Amyotrophic lateral sclerosis Flashcards
1
Q
What is the prognosis at diagnosis?
A
3-5 years
2
Q
What are the 2 most commonly found mutations in ALS?
A
C9orf72 and SOD1
3
Q
How is EPHA4 implicated in prognosis in ALS?
A
Lower EPHA4 = longer survival
4
Q
How does riluzole work?
A
Reduction of glutamate toxicity
Reduces rates of death or tracheostomy
