Amyloidosis Flashcards
1
Q
What is amyloidosis?
A
Disorders characterised by deposition of amyloid protein , extrazellular
2
Q
In which condition is amyloid deposition a characteristic feature ?
A
Alzheimer’s
3
Q
What are the 3 types of amyloidosis ?
A
AL Amyloid
AA amyloid
Familiar amyloidosis
4
Q
Which conditions are assoc with AL Amyloid deposition?
Which organs might be involved ?
A
Multiple myeloma
Lymphoma
Waldenström
Kidney , heart, gut, nerves , vessels
5
Q
How can a AA amyloid deposition present? What does it indicate ?
Which conditions are associated ?
A
Indicates chronic inflammation
- rheumatoid arthritis
- UC/ Crohns
- TB
- Osteomyelitis
Presents with nephrotic syndrome and hepatosplenomegaly as kidneys liver and spleen involved
6
Q
What causes familial amyloidosis ?
What’s the cure?
A
Mutation on transthyretin
Liver transplant
