AMU Flashcards
How do penicillins work
Bactericidal antibiotic
What types of bacteria do penicillins work against
obligate anearobes and gram positive aerobes
Can penicillin enter the CNS
yes if in high doses
Can penicillin be used in pregnant animals
Yes
what are aminopenicillins
amoxicillin, ampicillin
better stabilist and less resistance
How do cephlasporins work
bactericidal
What bacteria do cephalopsporins work against
gram positive aerobes
ocasionally gram negative aerobes and obligate anaerobes
Do cephalosporins cross the placenta
Yes
why are cephalosporins good intramammary
they have low lipid solubility and therefore become trapped in the udder
are cephalosporins safe to use in pregnant animals
Yes
Describe the 4 types of cephalosporins
1st generation- poor gram neg but good gram positive
2nd generation - poor gram positive and negative
3rd generation - good gram positive, variable gram negative
4th generation - broad spectrum
how do potentiated sulphonamides work
bactericidal
which bacteria do potentiated sulphonamides work against
some anaerobes
gram positive+negative aerobes
chlamydia?
what deactivates potentiated sulphonamides
organic material - pus
can potentiated sulphonamides be used in pregnant animals
yes
tetracycline method of action
bacteriostatic
what bacteria do tetracyclines work against
gram positive/negative
atypical (mycoplasma) and spirochetes
what type of antibioitcs are good for the respiratory tract
tetracyclines
are tetracyclines safe in pregnant animals
yes
what bacteria are aminoglycosides effective against
gram negative aerobes
are aminoglycosides safe in pregnant animals
Yes
what aminoglycoside is banned for use in food producing animals
gentamycin
what is th effect of aminoglycosides and penicillins together
synergistic bactericidal activity
macrolides method of action
bacteriostatic
what bacteria do macrolides work against
gram positive - some effect on mycoplasma as well
are macrolides safe in pregnant animals
yes
