AMT exam 4 Flashcards
solid tumor markers
BRCA 1/2 mutation
Li-Fraumanei syndrome
Ataxia telangiecastia
Von Hippel-Lindau
Lynch syndrome
hereditary cancer
mutations happens ONLY in the TUMOR
Somatic mutation
loss of function mutations
tumor suppressor genes
gain off function mutations
oncogenes
How is somatic mutation testing done?
tumor is excited by surgery or biopsy of specimen
establish that a disease is present in the patient
diagnostic
association with clinical outcomes such as surgical or recurrence-free survival independent of treatment
prognostic
predict activity of a certain therapy response
predictive
type of predictive marker that infers resin to particular drug
companion diagnostic
p53 mutation indices more aggressive cancer
HER2/neu over expression indicates growth and metastasis of breast cancer
examples of prognostic
Giloma, Breast, Colorectal, non-small cell lung cancer, Ewing sarcoma, synovial sarcoma, rhabdomyosarcoma
examples of solid tumors
What is the only loss of mutation talked about in lecture
PTEN (tumor suppressor)
solid tumor with tissue of origin from epithelial cells
carcinomas
solid tumor with tissue of origin from bone, cartilage, muscle, blood vessels, fat
Sarcomas
movement of dislodged tumor cells for the original site to other locations
Metastasis `
promote cell division
oncogenes
slow down or stop cell division by counteracting the movement of cell from G1 to S or G2 to M phase
tumor suppressor gene role
cytokeratin genes
gastric cancer
carcinoembryonic antigen
breast cancer
rearranged immunoglobulin or T-cell receptor genes
lymphoma
not present in normal cells and are more definitive with respect to the detection of a tumor
tumor-specific targets
carry oncogenic mutations that can be detected in blood or other body fluids
cell free nucleic acids or circulating tumor cells
this protein is required for cell to grow and divided
her2/neu
predictor of a more aggressive growth and metastasis of the tumor cells
her2/neu prediction
