Amphetamine

Question 1

What are amphetamines and there classifcation

Answer 1

A group of synthetic drugs based on the amphetamine structure. Part of the phenylethylamine group of compounds.
Amohetamines are Class B, schedule II drug.
Methamphetamine is a class A, schedule II drug.

Question 2

Methods of use

Answer 2

Ingested orally
Snorted
Injected intravenously
Smoked

Question 3

Effects of Ecstacy

Answer 3

Alertness, enhanced self confidence, increase motivation, aggression, increased heart rate, blood pressure, body temperature and rate of breathing, anxiety, insomnia.
Long term effects - depression, cardiac arrest, amphetamine induced psychosis.

Question 4

Synthesis of amphetamine

Answer 4

Leukart reaction
Phenyl-2-propanone + ammonium formate —> amphetamine.

Question 5

Synthesis of methamphetamine

Answer 5

• Pheny-propanone + methylamine —> (in presence of mercuric chloride aluminium metal and ethanol)—> methamphetamine.
• Ephedrine —>(in presence of hydrogen iodine red phosphorus and ammonia and dry ice and acetone) —> methamphetamine.

Question 6

Analysis

Answer 6

Marquis colour test - Orange-brown in the presence of amphetamines and methamphetamine.
Confirmatory - GC-Ms or HPLC

Question 7

Classification of PCP (phencyclidine)

Answer 7

Class A, schedule II drug.

Question 8

Synthesis of PCP

Answer 8

Piperidine + cyclohexanone —> (presence of KCN and Na2SO3)—> PCC —>(presence of C6H5MgBr) —> PCP.