AML Introduction Flashcards

1
Q

What cytogenetic abnormalities are sufficient to

diagnose AML with MDS-related changes ?

A
  • complex karyotype (3 or more chromosomal abnormalities)
  • Unbalanced changes
  • Balanced changes

Note: presence of NPM1 or biallelic mutations of CEBPA excludes AML from this category.

see pg. 378 flow book for unbalanced and balanced changes

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2
Q

What are the precursor blastic

markers or precursor stage markers ?

A
  • CD34
  • CD38
  • CD117
  • CD133
  • HLA-DR
  • TdT
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3
Q

What are considered to be myeloid

markers ?

A
  • cytoplasmic MPO
  • CD13
  • CD33
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4
Q

When diagnosing an MPAL

(mixed phenotype acute leukemia), what

myeloid lineage markers are needed?

A
  • MPO
  • OR evidence of monocytic differentiation, with expression of at least 2 monocytic markers:
    • NSE
    • CD11c
    • CD14
    • CD64
    • Lysozyme
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5
Q

When diagnosing an MPAL

(mixed phenotype acute leukemia), what

B-lineage markers are needed?

A
  • CD19 (strong)
  • with at least one of the following:
    • CD79a
    • CD22
    • CD10
  • CD19 (weak) with at least two of the following:
    • CD79a
    • CD22
    • CD10
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6
Q

When diagnosing an MPAL

(mixed phenotype acute leukemia), what

T- lineage markers are needed?

A
  • CD3 (surface or cytoplasmic)
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