Amitraz, benzoamido

Question 1

Acaricide and tickicide (spot-on, collar, against varoasis)
• Activates α2 receptors
Clinicals signs:

Answer 1

• Sedation (may be prolonged for up to 72 hours), ataxia, CNS depression, bradycardia, hypotension, mydriasis, hyperglycaemia, constipation.

Question 2

Clinicals signs:

• In cats

Answer 2

also respiratory depression, hypothermia, prolonged QT interval, arrhythmias.

Question 3

Clinicals signs:

• In horses

Answer 3

also difficulties in chewing and swallowing, diminished cutaneous sensibility, diminished reflexes, stridor and abdominal breathing.

Question 4

Treatment:

Answer 4

yohimbin or atipamezole,

risk of worse constipation in activated charcoal

Question 5

Not recommended

Answer 5

• Not recommended to be handled by diabetic people and administered to diabetic animals
• Not recommended to cats and Chihuahua and other toy-breed dogs

Question 6

Benzimidazoles

Answer 6

• Popular anthelmintics
• Toxicity to bone marrow and gut mucosa – inhibition of mitosis
• Mammalian tubulin less sensitive, but still toxicity can appear
• Toxicity in dogs, cats and especially birds
• Cats develop also mental changes and neurological
symptoms
• In thiabendazole probably most negative effects – nephrotoxic, haemosiderosis and liver damage, lethargy, hair loss, rarely also toxic epidermal necrolysis
• From dogs, dachshunds are reported to be particularly susceptible to thiabendazole
• Developmental damage was revealed for several substances in laboratory animals and fish