Amiodorone Flashcards

1
Q

Amiodorone (Cordarone, Pacerone)

Class

A
  • Antiarrhythmic
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2
Q

Amiodorone (Cordarone, Pacerone)

MOA

A
  • Blocks sodium & myocardial potassium channels
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3
Q

Amiodorone (Cordarone, Pacerone)

Indications

A
  • VF/pulseless VT
  • Unstable VT refractory to other therapy
  • Persistant SVT refractory to other therapy
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4
Q

Amiodorone (Cordarone, Pacerone)

Contraindications

A
  • Hypersensitivity
  • Cardiogenic shock
  • Sinus bradycardia
  • 2nd or 3rd deg AV block (unless functional pacemaker available)
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5
Q

Amiodorone (Cordarone, Pacerone)

Adverse reactions

A
  • Bradycardia
  • Hypotension
  • Prolongation of:
    • PRI
    • QRS
    • QTi
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6
Q

Amiodorone (Cordarone, Pacerone)

Drug Interactions

A
  • Digoxin may cause digitalis toxicity
  • Antiarrhythmics may cause increased serum levels
  • Beta-blockers and calcium channel blockers may potentiate bradycardia, sinus arrest, & AV heart blocks
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7
Q

Amiodorone (Cordarone, Pacerone)

Adult Dosage

A

Adult:

  • **VF/pulseless VT **unresponsive to CPR, defib & pressors
    • 300 mg IV push, flush, 150 mg follow up dose
  • Recurrent life-threatening vent arrhythmias
    • Rapid infusion 150 mg IV over 10 min (15 mg/min)
      • May repeat rapid infusion q 10 min as needed
    • Slow infusion 360 mg IV over 6 hrs (1 mg/min)
    • Maintenance infusion 540 mg IV over 18 hrs (0.5mg/min)
    • Max total dose is 2.2g/24hrs
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8
Q

Amiodorone (Cordarone, Pacerone)

Ped Dosage

A

Ped:

  • Pulseless arrest (ie, VF/pulseless VT)
    • 5 mg/kg IV bolus
      • Can repeat 5mg/kg bolus to daily max of 15 mg/kg per 24 hrs
      • Max single dose is 300 mg
  • Perfusing SVT & VT
    • Loading dose of 5 mg/kg IV drip over 20-60 min
      • Max single dose is 300 mg
      • Can repeat to daily max of 15 mg/kg
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9
Q

Amiodorone (Cordarone, Pacerone)

Duration

A
  • Onset: Immediate
  • Peak: 10-15 min
  • Duration: 30-45 min
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10
Q

Amiodorone (Cordarone, Pacerone)

Special Considerations

A
  • Preg Cat: D
  • Monitor for hypotension
  • May worsen arrhythmias or precipitate new ones
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