Aminoglycosides

Question 0

Gentamicin

Answer 0

Anti-pseudomonal

Topically for wound/burn infections

Question 1

Aminoglycosides (group)

Answer 1

MOA: Inhibit protein synthesis-bind to 30s subunit (block initiation, prevent further translation/promote premature termination, promotes incorrect AA incorporation).
Uses: Severe systemic infections w/Gram neg
Coverage: Gram neg enterics, aerobes only (require O2 for transport into cell), bactericidal
Kinetics: IV only, does not penetrate CNS, kidney excretion
Can be combined w/penicillins but not in same syringe
AE: Serious ototoxicity and nephrotoxicity

Question 2

Tobramycin

Answer 2

Anti-pseudomonal

Question 3

Amikacin

Answer 3

Anti-Pseudomonal

Question 4

Streptomycin

Answer 4

Tularemia, TB, endocarditis, Plague

Question 5

Neomycin

Answer 5

Pre-op suppression of enteric aerobes and control severe diarrhea from E. coli
Tx of hepatic encephalopathy
Topically for wounds/burns

Question 6

Kanamycin

Answer 6

Pre-op suppression of enteric aerobic flora and control severe diarrhea from E. coli.

Question 7

Paromomycin

Answer 7

Intestinal amebiasis

Question 8

Spectinomycin

Answer 8

Not available in US
Tx of uncomplicated gonorrhea by single IM injection, for pts allergic to cetriaxone or b-lactams
CI: don’t use for tx of pharyngeal gonorrhea