Aminoglycosides

Question 1

Aminoglycosides

Answer 1

MOA: inhibit protein synthesis
gram - 
serious inf
not absorbed from GI
P. aeruginosa
Side effects: Ototoxicity, nephrotoxicity, renal fx, superinfection, confusion, GI prob, palpitations, hypersensitivity

Question 2

Amikacin

Answer 2

MOA: inhibits protein synthesis
Therapeutic: P. aeruginosa, meningitis, septicemia, bacteremia, resp/UTI
take when bacterial resistance to genta/tobra
DOSE: IM/IV 8-12hr
Side effects: 1- fever, headache, rash, GI,CDAD, anemia, superinf
Adverse ototox, neprhotox
Don’t take with…
Class: aminoglycoside

Question 3

Gentamycin

Answer 3

MOA: inhibit protein synthesis
Therapeutic: MRSA! meningitis, septicemia, bacteremia, resp/UTI
Use sunblock
caution with old, young
DOSE: IM, IV, 3 doses
Side effects: 1- thrombocytopenia, photosensitivity, headache, rash, GI, anemia, confusion, depression, conjunctivitis
Superinfection,
Adverse ototox, neprhotox, neurotox, anaphylaxis,
Don’t take with… vanco (glycopeptides). don’t mix with penicillin in soln. cephalosporins increase effect
Class: aminoglycoside

Question 4

neomycin sulfate

Answer 4

MOA: inhibit protein synthesis
Therapeutic: hepatic encephalopathy, skin infections, bowel prep
Use sunblock, preparative bowel antiseptic
caution with old, young
DOSE: PO, TOPICAL ………IM, IV, 3 doses
Side effects: 1- stomatitis, headache, rash, GI, itchy
Superinfection,
Adverse ototox, neprhotox, neurotox, anaphylaxis,
Don’t take with… vanco (glycopeptides). don’t mix with penicillin in soln. cephalosporins increase effect
Class: aminoglycoside

Question 5

Streptomycin sulfate

Answer 5

MOA: inhibit protein synthesis
Therapeutic: meningitis, endocarditis, plague, tuberculosis, bacteremia, resp/UTI
Use sunblock
caution with old, young
DOSE: IM, IV, 3 doses
Side effects: 1- fever, paresthesia, hearing loss, headache, rash, GI, anemia,
Superinfection,
Adverse ototox, neprhotox, neurotox, anaphylaxis,
Don’t take with… vanco (glycopeptides). don’t mix with penicillin in soln. cephalosporins increase effect
Class: aminoglycoside

infrequently used

Question 6

Tobramycin

Answer 6

MOA: inhibit protein synthesis
Therapeutic: meningitis, septicemia, bacteremia, resp/UTI, skin infections, bone/joint inf,
Use sunblock
caution with old, young
DOSE: IM, IV, 3 doses
Side effects: 1- dysphonia, chest pain, cough, fever, headache, rash, GI, anemia,
Superinfection,
Adverse ototox, neprhotox, neurotox, anaphylaxis,
Don’t take with… vanco (glycopeptides). don’t mix with penicillin in soln. cephalosporins increase effect
Class: aminoglycoside