amino acids Flashcards

1
Q

Alanine

A
  • Ala
  • non-polar hydrophobic
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2
Q

valine

A
  • non polar hydrophobic
  • aliphatic
  • highly hyrdophobic
  • Val
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3
Q

Leucine

A
  • Leu
  • aliphatic
  • non-polar hydrophobic
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4
Q

isolucine

A
  • Ile
  • aliphatic
  • non polar highly hydrophobic
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5
Q

phenylalanine

A
  • Phe
  • aromatic
  • non polar hydrophobic
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6
Q

trytophan

A
  • Trp
  • aromatic, heterocyclic, bulky
  • H-bond donor
  • non-polar hydrophobic
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7
Q

methionine

A
  • “honourary aliphatic
  • Met
  • thioether
  • non polar hydrophobic
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8
Q

proline

A
  • Pro
  • distinctive cuclic
  • secondary amino group
  • non polar hydrophobic
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9
Q

glycine

A
  • Gly
  • achiral
  • wealky polar
  • small and flexible
  • polar uncharged
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10
Q

serine

A
  • Ser
  • polar uncharged
  • hydroxyl group = H-bond donor
  • can be modified
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11
Q

threonine

A
  • Thr
  • OH group = typically H-bond donor
  • phosphorylated
  • polar uncharged
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12
Q

Tyrosine

A
  • weakly polar
  • polar uncharged
  • OH grp = typically H-bond donor
  • can be phosphorylated
  • pKA = ~10.5
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13
Q

cysteine

A
  • Cys
  • polar uncharged
  • SH can form H-bonds
  • can form S- (thiolate anions)
  • disulphide bonds with another cys; in oxidizing envionemtns (not cytosolic)
  • create cross links
  • pKa = 8.5
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14
Q

Asparagine

A
  • Asn
  • polar uncharged
  • forms H-bonds; NH2 donor, C=O acceptor
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15
Q

Glutamine

A
  • Gln
  • polar uncharged
  • carboxamine
  • H-bonds; NH2, donor C=O accpetor
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16
Q

Histidine

A
  • His
  • polar uncharged
  • imidazole ring (aromatic)
  • residues important for enzyme catalyzation
  • H-bond: Donor=acid;acceptor=base
  • pKa =6.0
17
Q

aspartate

A
  • Asp
  • polar charged
  • acidic amino acid
  • H-bond acceptor ( 2 for each carbon)
  • aspartic acid - at pH 1
  • pKa = 4.0
18
Q

Glutamate

A
  • Glu
  • polar charged
  • H-bond acceptor
  • glutamic acid - at pH 1
  • pKa = 4.0
19
Q

Lysine

A
  • Lys
  • basic amino acid
  • H-bond donor
  • pKa = 10.0
20
Q

Arginine

A
  • guanido group
  • basic amino acid
  • H-bon donor (5 possible bonds on N)
  • due to resonance structure
  • pKa = 12.5