Amino Acid Side Chains Flashcards
1
Q
Aliphatic hydrophobic amino acids
A
Alanine -CH3 Valine -CH(CH3)2 Leucine -CH2CH(CH3)2 Isoleucine -CH(CH3)CH2CH3 Methionine -CH2CH2SCH3
2
Q
Aromatic amino acids
A
Phenylalanine -CH2-C6H5 (hydrophobic)
Tyrosine -CH2-C6H4-OH
Tryptophan -NH can form H-bonds but molecule mainly hydrophobic
3
Q
Uncharged polar hydrophilic amino acids
A
Asparagine -CH2C=ONH2
Glutamine -CH2CH2C=ONH2
*amide group is polar but does not ionise so less hydrophobic
Serine -CH2OH
Threonine -CHOHCH3
*OH is polar so forms H-bonds so is hydrophilic
4
Q
Ionised hydrophilic amino acids
A
Aspartic acid -CH2COOH Glutamate -CH2CH2COOH *Acidic COOH side chain - hydrophilic Lysine -C4H8NH3+ Arginine -C3H6NHC=NH2+NH *Strong basic side chains Histidine -CH2-(cyclic C-NH=CH-NH-CH=) *Weakly basic pKa=6 -side chains form H-bonds + salt bridge
5
Q
Amino acids with unusual properties
A
Cysteine -CH2SH
*Forms disulphuide bridges
Proline -NH2 imino group - hydrophobic
*Puts a kink into conformation of polypeptide chains