amines

Question 1

synthesis of aryl amines

Answer 1

reduction of nitro compounds
-treat with H2 and a nickle catalyst
or
-treat witFe, Sn, or Zn in dilute acid followed by addition of a base

Question 2

production of diazonum salts

Answer 2

-Treatment of an aromatic amine with a HN02

Question 3

reactions of diazonium salts

Answer 3

• warming solution yields a phenol and nitrogen gas
• treating with H3PO2 replaces diazonium group with H
• treatment with CuCN replaces dizonium group with CN which can then be easily hydrolysed to the carboxylic acid

Question 4

Gabriel synthesis

Answer 4

• treatment of phthalamide with a base
• reaction of pthalamide ion with alkylhalide
• hyrdolysis of N-substituted thalamide, (H+,H20) yields alkyl ammonium ion and phtalic acid
• treatment with a base yields primary amine

Question 5

reduction of amides 1

Answer 5

1) addition of lithium aluminium hydride

2) addition of dilute HCL

Question 6

reduction of amides 2

Answer 6

Formation of an imine then reduction
1) treatment of a ketone with a primary amine (forms imine)
2) addition of NaBH4 (reduced imine)
yields a secondary amine

Question 7

metabolism of amines

Answer 7

Cytochrome P450 enzymes (monooxygenases)