Amenorrhea Flashcards
What key history would you obtain from a patient who complains of amenorrhea?
Primary vs. secondary
Duration
Possible pregnancy
ASSOCIATED SYMPTOMS (headache, decreased peripheral vision, galactorrhea, hirsuitism, virilization, hot flashes, vaginal dryness, symptoms of thyroid disease)
History of anorexia nervosa, excessive dieting, vigorous exercise, pregnancies, D&Cs uterine infections
Drug use
Medications
What key physical exams would you perform on a patient who complains of amenorrhea?
Vital signs
Breast exam
Complete pelvic exam
40 yo F presents with amenorrhea, morning nausea and vomiting, fatigue and polyuria. Her last menstrual period was six weeks ago and her breasts are full and tender. She uses the rhythm method for contraception. Differentials?
Pregnancy Anovulatory cycle Hyperprolactinemia UTI Thyroid disease
40 yo F presents with amenorrhea, morning nausea and vomiting, fatigue and polyuria. Her last menstrual period was six weeks ago and her breasts are full and tender. She uses the rhythm method for contraception. Differentials: pregnancy, anovulatory cycle, hyperprolactinemia, UTI, thyroid disease. Workup?
Pelvic exam Urine hCG U/S - pelvis CBC, electrolytes UA, urine culture Prolactin TSH Baseline Pap smear, cervical culture, rubella antibody, HIV antibody, hepatitis B surface antigen, and VDRL/RPR
23 yo obese F presents with amenorrhea for six months, facial hair and infertility for the past three years. Differentials?
Polycystic ovary syndrome Thyroid disease Hyperprolactinemia Pregnancy Ovarian or adrenal malignancy Premature ovarian failure
23 yo obese F presents with amenorrhea for six months, facial hair and infertility for the past three years. Differentials: polycystic ovary syndrome, thyroid disease, hyperprolactinemia, pregnancy, ovarian or adrenal malignancy, premature ovarian failure. Workup?
Pelvic exam Urine hCG Prolactin LH/FSH TSH MRI - brain
35 yo F presents with amenorrhea, galactorrhea, visual field defects and headaches for the past six months. Differentials?
Amenorrhea secondary to a prolactinoma (cabergoline -1st; bromocriptine - 2nd) Pregnancy Thyroid disease Premature ovarian failure Pituitary tumor
35 yo F presents with amenorrhea, galactorrhea, visual field defects and headaches for the past six months. Differentials: amenorrhea secondary to a prolactinoma, pregnancy, thyroid disease, premature ovarian failure, pituitary tumor. Workup?
Pelvic and breast exam Urine hCG Prolactin LH/FSH TSH MRI - brain
48 yo F presents with amenorrhea for the past six months accompanied by hot flashes, night sweats, emotional lability, and dyspareunia. Differentials?
Menopause
Pregnancy
Pituitary tumor
Thyroid disease
48 yo F presents with amenorrhea for the past six months accompanied by hot flashes, night sweats, emotional lability, and dyspareunia. Differentials: menopause, pregnancy, pituitary tumor, thyroid disease. Workup?
Pelvic exam Urine hCG LH/FSH TSH Prolactin, testosterone, DHEAS CBC MRI - brain
35 yo F presents with amenorrhea, cold intolerance, coarse hair, weight loss and fatigue. She has a history of abruptio placentae followed by hypovolemic shock and failure of lactation two years ago. Differentials?
Sheehan's syndrome Premature ovarian failure Pituitary tumor Thyroid disease Asherman's syndrome
35 yo F presents with amenorrhea, cold intolerance, coarse hair, weight loss and fatigue. She has a history of abruptio placentae followed by hypovolemic shock and failure of lactation two years ago. Differentials: Sheehan’s syndrome, premature ovarian failure, pituitary tumor, thyroid disease, Asherman’s syndrome. Workup?
Pelvic exam Urine hCG CBC LH/FSH Prolactin TSH, FT4 ACTH MRI - brain Hysteroscopy
18 yo F presents with amenorrhea for the past four months. She has lost 95 pounds and has a history of vigorous exercise and cold intolerance. Differentials?
Anorexia nervosa
18 yo F presents with amenorrhea for the past four months. She has lost 95 pounds and has a history of vigorous exercise and cold intolerance. Differentials: anorexia nervosa. Workup?
CBC
TSH, FT4
ACTH
FSH/LH
29 yo F presents with amenorrhea for the past six months. She has a history of occasional palpitations and dizziness. She lost her fiance in a car accident. Differentials?
Anxiety-induced amenorrhea