Amblyopia II Flashcards

1
Q

Optical correction for anisometropia amblyopia objective

A

Evaluate the effectiveness of refractive correction alone for the treatment of untreated anisometropic amblyopia in children younger than 7

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2
Q

Outcome of optical correction for anisometropic amblyopia

A

Max improvement in VA in the anlyopic eye and proportion of children whose amblyopia resolved with refractive correction alone

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3
Q

Results of optical correction for anisometropic amblyopia

A

Amblyopia improved with correction by >2 lines in 77%
Resolved in 27%
Improvement mostly about 15 weeks

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4
Q

Notes about optical correction for anisometropic amblyopia

A

Outcome was not related to age, but was related to better baseline visual acuit and lesser anisometropia
-most resolution occurred in cases with moderate amblyopia

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5
Q

Conclusion of optical correction for anisometropic amblyopia

A

Refractive correction alone improves VA in many cases and results in resolution of amblyopia in at least 1/4 of childrenyounger than 7 with untreated anisometropia amblyopia

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6
Q

Objective of pathcing vs atropine in kids 7-12

A

RCT to compare pathcing and atropine as treatmetn of moderate amblyopia in children aged 7-12

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7
Q

Outcome of pathcing vs atropine in kids 7-12

A

Average VA improvement from baseline

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8
Q

Results of patching vs atropine in children 7-12

A
Pathcing group: 8.6 letters 
Atropine group: 7.6 letters 
VA >20/25 in the amblyopic eye 
Patching group: 24%
Atropine group: 17%
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9
Q

Notes about patching vs atropine in kids 7-12

A

Mean difference between the 2 groups adjusted for baseline acuity was 1.2 letters

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10
Q

Conclusion of patching vs atropine in kids 7-12

A

Treatment with atropine or pathcing produced similar improvement in the treatment of moderate amblyopia in children 7-12

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11
Q

Near activity pathcing objective

A

To determine if performing near activities, which patching for amblyopia, enhances improvement in VA

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12
Q

Outcome of near activity with patching

A

Improvement in amblyopic eye VA at 8 weeks

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13
Q

Results of near activity patching

A
  • distance activity group: 2.6 lines

- near activity group: 2.5 lines

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14
Q

Notes about near activity patching

A

At 17 weeks, children with severe amblyopia improved with 2 hours pathcing

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15
Q

Conclusion of near activity with patching

A

Near activities does not improve VA outcome when treating anismetropic, strabismic or combined amblyopia with two hours of daily pathcing

Children with severe amblyopia (20/100-20/400) May respond to two hours of daily pathcing

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16
Q

Weekend atropine with plan lenses vs atropine alone objective

A

To compare weekend atropine augmented by a Plano lens for the sound eye vs weekends atropine alone for moderate amblyopia in children 3 to <7 years old

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17
Q

Outcome of weekend atropine with Plano lens vs atropine alone

A

VA in amblyopic eye at 18 weeks

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18
Q

Results of weekend atropine with Plano lens vs atropine alone

A

Amblyopic eye improvement in atropine plus Plano lens group: 2.8 lines

Amblyopic eye improvent in atropine alone group: 2.4 lines

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19
Q

Note about weekend atropine with Plano lens vs atropine alone

A

More patients in the atropine with optical penzalization group had reduced sound eye acuity at 18 weeks; however, there were no cases of persistent reverse amblyopia

20
Q

Conclusion of weekend atropine with Plano lenses vs atropine alone

A

As an inital treatment for moderate amblyopia, the augmentation of one drop of weekend atropine with a Plano lens does not substantially imrpove amblyopic eye acuity when compared with atropine alone

21
Q

Objective of patching vs bangerter occlusion filter

A

Too determine whether VA improvement with Bergerter filters is similar to improvement with pathcing as inital therapy for children with moderate amblyopia

22
Q

Outcome of patching vs bangerter occlusion filter

A

VA in amblyopic eyes at 24 weeks

23
Q

Results of patching vs bangerter occlusion filter

A

Amblyopic eye improvement with bangerter filter: 1.9 lines

Amblyopic eye improvement with patching: 2.3 lines

> 3 line improvement
Bangerter filter group: 38%
Pathcing group: 35%

24
Q

Notes on patching vs bangerter occlusion filter

A

Lower treatment burden in the bangerter group as measured with the amblyopia treatment index
Could change the density of the filter
Compliance may be better
No difference between treatment groups in stereoacuity

25
Q

Conclusion of patching vs bangerter occlusion filter

A

Bangerter filter treatment is a reasonable option to consider for initial treatment for moderate amblyopia. You need to monitor compliance

26
Q

Objective of intense final punch of patching and atropine

A

To determine whether an intensive final push with combined pathcing and atropine can improve VA in children with residual amblyopia

27
Q

Outcome with intense final push of pathcing and atropine

A

Improvement in VA of hte amblyopic eye

28
Q

Rustles of intense final push of pathcing and atropine

A

No significant difference in the improvement of VA between the groups

29
Q

Notes of intense final push of patching and atropine

A

The study was DCed because of slow recruitment and a poor confditional power analysis

Included because of the salvaged data

30
Q

Conclusion of intense final push of pathing and atropine

A

For kids who have already stopped improving (VA at 20/32-20/63) with 6 hours daily pathcing or with dailiy atropine, a further intensive final push of combined treatment with patching and atropine did not give a abetter VA outcome after 10 weeks compared with a control group in whom treatment was gradually DCed

31
Q

Objective of effect off optical correction alone on amblyopia

A

To determine VA improvement in kids withstrabismic and combined strab-anismetropic amlboypia treated with optical correction alone and to explore factors associated with improvement

32
Q

Results of effect of optical correction alone on amblyopia

A

Children with resolution of amblyopia: 32%
Treatment effect for strab amblyopia: 3.2 lines
Treatment effect for combined mechanism amblyopia: 2.3 lines

33
Q

Notes of effect of optical correction alone on amblyopia

A
  • VA improved regardless of whether eye alignment improved-shows the importance of optical correction
  • children were previously not treated
  • authors gave 2 possible hypotheses for improvements in VA of amblyopic eye. VA improvement might be associated with: improvement in ocular alignment OR improved retinal image clarity, despite persistent strab
34
Q

Conclusion of effect of optical correction alone on amblyopia

A

Optical correction alone for strab and combined amblyopia gives VA improvement in amblyopic eye for most 3-7 years old kids, resolving in at least 1/4 without the need for additional treatment

Consider Rxing refractive correction as the sole inital treatment for children with strab or combined mechanism amblyopic before starting other therapies

35
Q

Increasing daily pathcing for residual amblyopia objective

A

To evaluate the effectiveness of increasing daily pathcing from 2 to 6 hours in kids with stable residual amblyopia

36
Q

Results of increasing daily pathcing for residual amblyopia

A

Mean amblyopic eye VA improvement in 6 hour: 1.2 lines
Mean amblyopic eye VA imrpveoment in 2 hours: 0.5 lines
>2 line improvement
6 hours pathcing group: 40%
Continued 2 hours patching group: 18%

37
Q

Notes about increasing daily pathcing for residual amblyopia

A

Children in this study were 3-8 with stable residual amblyopia for about 12 weeks

38
Q

Conclusion of increasing dialing patching for residual amblyopia

A

When amblyopic eye VA stops improvement with 2 hours of daily patching increasing the daily percentage dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily

39
Q

Objective as levodopa as TX for residual amblyopia

A

To assess the efficacy and short term safety of levodopa as additional treatment to pathcing for amblyopia

40
Q

Results of levodaop for residual amblyopia

A

VA imrpveoemtn in levodopa: 5.2 letters
VA improvement in placebo: 3.8 letters

  • 20/30 or > 3 line imrpove net
  • patching: 79%
  • levodopa: 74%
41
Q

Notes about levodaop as treatment for residual amblyopia

A

There is nos evidence of a deficiency of dopamine in amblyopes, but levodopa has been used in studies of amblyopia treatment

No serious adverse effects from levodopa were reported during treatment
No dyskinesia

42
Q

Conclusion of levodopa for amblyopia

A

Does not improve

43
Q

VA improvement in BV activities vs pathcing objective

A

To compare VA improvement in children with amblyopia treated with a BV iPad game vs part time pathcing in kids aged 5 yo younger than 13

44
Q

Results of BV activities vs pathcing

A

BV: 1.05 lines
Patching: 1.35 lines

45
Q

Notes about BV vs pathcing for amblyopia

A

Amb,topic eye VA improved with BV game play with patching

46
Q

Conclusion of BV activities vs patching

A

Analysis suggested that VA improvement with this particular BV iPad game was not as goof as with 2 hours of Rxed daily pathcing