Amanda Bridges

Question 1

Branches of axillary artery

Answer 1

Superior thoracic artery
Thoraco-acromial artery
Lateral thoracic artery

Subscapular artery
Anterior circumflex humeral artery
Posterior circumflex humeral artery

Question 2

Mechanisms of action of NSAIDs

Answer 2

Non-selective NSAIDs: Reversibly inhibits both COX-1 and COX-2
Selective NSAIDs: Reversibly inhibits COX-2 only

Question 3

What does COX 1 do

Answer 3

Synthesis of prostaglandins that play role in GI mucosal protection (prevents ulceration and gastritis) , platelet aggregation, renal function

Question 4

What does COX-2 do?

Answer 4

Involved in production of prostaglandins that mediate pain and support the inflammatory process e.g. body temp

Question 5

Which COX does aspirin inhibit

Answer 5

COX-1

Question 6

Why is low dose aspirin for secondary CV protection and standard NSAIDs contraindicated

Answer 6

NSAIDs deactivate the anti-thrombotic effect of aspirin - risk of CV events

Question 7

Which COX is inducible (i.e. only produced by body when it is needed) and what inducers are associated with it

Answer 7

COX -2 ; cytokines and growth factors

Question 8

PGD2 role

Answer 8

Regulation of body temp and sleep-wake cycle

Question 9

What does COX enxyme convert

Answer 9

Converts arachidonic acid to prostaglandin

Question 10

Where are PGE2 receptors found

Answer 10

Brain, kidney, vascular smooth muscle cells, platelets

Question 11

What does COX convert arachidonic acid to

Answer 11

PG (PGE2, PGD2)
Thromboxane A2
Prostacyclin (PGI2)

Question 12

Prostaglandin D2 (PGD2) is involved in a wide variety of neurophysiological functions, such as:

Answer 12

Airway constriction, mucus secretion, increased microvascular permeability and recruitment of eosinophils observed in asthma, allergic rhinitis and other immune diseases

Upregulates production of pro-inflammatory cytokines, IL-4, IL-5 and IL-13 by human Th2 cells