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Pharm Test 3 > Alzheimers > Flashcards

Alzheimers Flashcards

1
Q

What kind of drug is donepezil?

A

cholinesterase inhibitor

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2
Q

What kind of drug is memantine?

A

NMDA antagonist

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3
Q

What is first line therapy for behavioral issues r/t alzheimers?

A

DMDA antagonist
-memantine? idk how to spell this
also cholinesterase inhibitors?

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4
Q

MOA of memantine

A

blocks glutamatergic neurotransmission by antagonizing NMDA receptors
-BLOCKS Ca INFLUX

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5
Q

Whats the MC AE of cholinesterase inhibitors?

A

GI upset

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6
Q

What kind of drug is glantamine?

A

cholinesterase inhibitor

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7
Q

Which is the only anticholinergic that is OK to use w/parkinsons?

A

rivastigmine

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8
Q

What kind of drug is rivastigmine?

A

cholinesterase inhibitor

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9
Q

MOA of rivastigmine

A

inhibits butylcholinesterase and acetylcholinesterase

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10
Q

What is first line treatment for alzheimers?

A

memantine + cholinesterase inhibitor

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11
Q

Glutamate is an ______________ neurotransmitter

A

excitatory

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12
Q

Which anticonvulsants are used to treat agitation or aggression associated w/alzheimers?

A

carbamazepine

valproic acid

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13
Q

MOA of ginkgo biloba

A

use ASAP

thought to prevent damage of membranes by free radicals

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14
Q

MOA of semagacestat

A

inhibits enzyme gamma-secretase lower the production of beta amyloid

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15
Q

What is Coenzyme Q10?

A

natural antioxidant

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16
Q

What drug can you use for mild to severe disease?

A

donepezil

17
Q

What drug can you use for mild to moderate?

A

galantamine

rivastigmine

18
Q

MOA of donepezil

A

specifically and reversibly inhibits acetylcholinesterase

19
Q

MOA of galantamine

A

selective, competitive, reversible acetylcholinesterase inhibitor and also enhances the action of acetylcholine onn nicotinic receptors

20
Q

What are the antipsychotics commonly used in the tx of alzheimers?

A 
haloperidol
olanzapine
quetiapine
risperidone
ziprasidone
21
Q

____% of alzheimers pt suffer from depression

A

50

22
Q

What are the anticonvulsants often used in treating alzheimers?

A

carbamazepine

valproic acid

23
Q

What are the antidepressants used in treating depression associated with alzheimers?

A 
citalopram
escitolipram 
fluoxetine
paroxetine
sertraline
venlafaxine
trazadone

Pharm Test 3 (5 decks)

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