Alzheimers Flashcards
What kind of drug is donepezil?
cholinesterase inhibitor
What kind of drug is memantine?
NMDA antagonist
What is first line therapy for behavioral issues r/t alzheimers?
DMDA antagonist
-memantine? idk how to spell this
also cholinesterase inhibitors?
MOA of memantine
blocks glutamatergic neurotransmission by antagonizing NMDA receptors
-BLOCKS Ca INFLUX
Whats the MC AE of cholinesterase inhibitors?
GI upset
What kind of drug is glantamine?
cholinesterase inhibitor
Which is the only anticholinergic that is OK to use w/parkinsons?
rivastigmine
What kind of drug is rivastigmine?
cholinesterase inhibitor
MOA of rivastigmine
inhibits butylcholinesterase and acetylcholinesterase
What is first line treatment for alzheimers?
memantine + cholinesterase inhibitor
Glutamate is an ______________ neurotransmitter
excitatory
Which anticonvulsants are used to treat agitation or aggression associated w/alzheimers?
carbamazepine
valproic acid
MOA of ginkgo biloba
use ASAP
thought to prevent damage of membranes by free radicals
MOA of semagacestat
inhibits enzyme gamma-secretase lower the production of beta amyloid
What is Coenzyme Q10?
natural antioxidant
What drug can you use for mild to severe disease?
donepezil
What drug can you use for mild to moderate?
galantamine
rivastigmine
MOA of donepezil
specifically and reversibly inhibits acetylcholinesterase
MOA of galantamine
selective, competitive, reversible acetylcholinesterase inhibitor and also enhances the action of acetylcholine onn nicotinic receptors
What are the antipsychotics commonly used in the tx of alzheimers?
haloperidol olanzapine quetiapine risperidone ziprasidone
____% of alzheimers pt suffer from depression
50
What are the anticonvulsants often used in treating alzheimers?
carbamazepine
valproic acid
What are the antidepressants used in treating depression associated with alzheimers?
citalopram escitolipram fluoxetine paroxetine sertraline venlafaxine trazadone
