Alzheimer's Flashcards
1
Q
Name an Alzheimer’s drug that acts as an AChEI (also inhibits BuChE) and has potential side effect of elevating transaminases. This is now an obsolete drug, but you better know it anyway!
A
Tacrine
2
Q
Which AChEIs are metabolized by P450?
A
- tacrine, donepezil, galantamine
3
Q
This drug inhibits both AChE and BuChE, is hydrolyzed by cholinesterases, and is dosed 2x/day
A
- rivastigmine
4
Q
How does galantamine work?
A
- inhibits AChE
- allosteric modulation of nicotinic receptors
5
Q
Tell me about memantine: how does it work? What are some interesting side effects (based on what it is supposed to be treating)? How is it metabolized?
A
- partial antagonist of NMDA receptor
- SE: dizziness, confusion, HA, constipation
- excreted unchanged in urine!
6
Q
What are common side effects to all AChEIs?
A
- nausea/vomiting
- diarrhea
- sleep disturbance
