Alzheimer Disease

Question 1

Outline the characteristic clinical features of Alzheimer disease

Answer 1

1) Gradual cognitive decline
2) Earliest deficit in short term recent memory
3) Early deficit in language and visuospatial skills
4) Late deficit in executive function
5) Later develop BPSD, EPS, myoclonus, seizures

Question 2

State the inheritance of Alzheimer disease

Answer 2

Autosomal dominant

Question 3

Outline the genes involved in Alzhimer disease

Answer 3

Early onset (

Question 4

Outline the pathology seen in Alzheimer disease

Answer 4

1) Hippocampal atrophy
2) β-amyloid plaque retention
3) tau neurofibrillary tangles