ALTEPLASE RECOMBINANT (tPA) (Activase) Flashcards
ALTEPLASE RECOMBINANT (tPA) (Activase)
Name/Class: ALTEPLASE RECOMBINANT (tPA) (Activase)/Thrombolytic
Description: Recombinant DNA–derived form of human tPA promotes thrombolysis by
forming plasmin. Plasmin, in turn, degrades fibrin and fibrinogen and, ultimately, the clot.
Indications: To thrombolyse in acute myocardial infarction, acute ischemic stroke, and
pulmonary embolism.
Contraindications: Active internal bleeding, suspected aortic dissection, traumatic CPR, recent hemmorhagic
stroke (6 months), intracranial or intraspinal surgery or trauma (2 month), pregnancy, uncontrolled hypertension,
or hypersensitivity to thrombolytics.
Precautions: Recent major surgery, cerebral vascular disease, recent GI or GU bleeding, recent trauma,
hypertension, patient > 75 years, current oral anticoagulants, or hemorrhagic
ophthalmic conditions.