ALS

Question 1

Terminal progressive disease involving both UMNL and LMNL

Answer 1

ALS

Question 2

UMN and LMN signs in the bulbar region and at least 2 spinal regions

Answer 2

Clinically Definite

Question 3

UMN and LMN clinical signs in 2 regions with at least 1 UMN finding rostral to the LMN findings

Answer 3

Clinically Probable

Question 4

UMN signs alone present in 1 region and LMN defined by by EMG criteria present in at least 2 regions

Answer 4

Clinical Probable with Laboratory Support

Question 5

LMN signs found rostral to UMN signs and the inability to establish a diagnosis of clinically probable laboratory supported

Answer 5

Clinically Possible

Question 6

CN Involvement

Answer 6

Trigeminal, facial, glossopharyngeal, vagus and hypoglossal

Question 7

Cardinal sign

Answer 7

Muscle weakness

Question 8

Limb loss onset

Answer 8

70-80%

Question 9

Bulbar loss onset

Answer 9

20-30%

Question 10

Early Signs

Answer 10

Muscle cramps, weakness, atrophy and fatigue

Question 11

Spreads regionally with ____ symptoms occurring before ____

Answer 11

Distal; Proximal

Question 12

Bulbar signs commonly occur ___

Answer 12

Later

Question 13

LMN characteristics include

Answer 13

Hyporeflexia, decreased muscle tone or flaccidity, muscle cramping

Question 14

UMN characteristics include

Answer 14

Spasticity, hyperreflexia, clonus, Babinski