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ANESTHESIA DRUGS Vet Tech > Alpha2 Agonist Drugs > Flashcards

Alpha2 Agonist Drugs Flashcards

1
Q

Name 4 alpha2-agonist drugs.

A

Xylazine
Dexmedetomidine
Detomidine
Romifidine

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2
Q

What is the method of action for xylazine/dexmedetomidine detomidine/romifidine?

A

Act on alpha2 receptors in the SNS (both in CNS and periphery), causing a decrease in the release of the neurotransmitter norepinephrine —> no “fight or flight” response.

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3
Q

How are xylazine/dexmedetomidine detomidine/romifidine administered?

A

IM or IV

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4
Q

Are the drugs xylazine/dexmedetomidine detomidine/romifidine controlled or non-controlled?

A

Non-controlled

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5
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the CNS?

A

+ effects:
+ sedation
+ short-acting analgesia
+ potentiate other anesthetic agents

  • effects:
  • can cause changes in behavior
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6
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the cardiovascular system?

A

+ effects:
None

  • effects:
  • bradycardia
  • hypotension
  • arrhythmias
  • decreases cardiac output
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7
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the respiratory system?

A

+ effects:
None

  • effects:
  • respiratory depression (more severe if given with other drugs)
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8
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the GI system?

A

+ effects:
None

  • effects:
  • vomiting (cats and dogs), salivation & regurgitation (cattle)
  • increased urination (metabolized in lover, excreted in urine)
  • bloat (dogs, horses, cattle)
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9
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the musculoskeletal system?

A

+ effects:
+ muscle relaxation

  • effects:
    None
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10
Q

What effects do xylazine/dexmedetomidine detomidine/romifidine have on the reproductive system?

A

+ effects:
None

  • effects:
  • premature parturition
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11
Q

What is the reversal agent for xylazine?

A

Yohimbine

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12
Q

What is the reversal agent for dexmedetomidine?

A

Atipamezole

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13
Q

What is the nonspecific reversal agent for alpha2-agonists?

A

Tolazoline

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14
Q

What precautions should you take if you have skin contact with xylazine/dexmedetomidine detomidine/romifidine?

A

Wash off area immediately. (Alpha2-agonists can be easily absorbed through skin abrasions and mucous membranes.)

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15
Q

When using Dexdomitor 0.5 and Antisedan, how are reversal volumes of Antisedan calculated?

A

Dogs: same volume of Antisedan as Dexdomitor 0.5

Cats: a little more than half the volume of Antisedan as Dexdomitor 0.5 (cats are more sensitive to the effects of atipamezole)

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ANESTHESIA DRUGS Vet Tech (5 decks)

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