Alpha1 blockers

Question 1

names

Answer 1

“azosins”

Question 2

MOA

Answer 2

block peripheral a1 receptors in arterioles and venules

Question 3

effect

Answer 3

decreased TPR and BP

relieve symptoms of BPH by relaxing muscles of bladder and prostate

Increase HDL
Lower LDL
beneficial effect on insulin resistance

Question 4

clinical uses…Prazosin

Answer 4

antihypertensive

Monotherapy not recommended w/ any a1 blockers

Question 5

Terazosin and Doxazosin

Answer 5

treatment of symptoms of BPH, urinating and bladder emptying problems, etc.

Also lower BP

Question 6

Treatment of choice for older men w/ HTN and prostate problems

Answer 6

Terazosin or Doxazosin

Question 7

Side effects

Answer 7

First dose orthostatic hypotension common w/ short-acting drug
**i.e. prazosin

dizziness, vertigo, drowziness, palpitations

Question 8

Nonselective alpha adrenergic blockers

Answer 8

Phentolamine and Phenoxybenzamine
Given IV in hospital setting
used to control BP in Pheocromocytoma

Question 9

ALLHAT studies

Answer 9

concluded alpha-1 blockers not good for monotherapy