Alpha 2 Adrenergic Agonists

Question 1

Clonidine

Answer 1

Acts on cardiovascular center in CNS. Modulates CNS perception to pain. Induces sedation. Increase bioavailability. Renal blood flow not altered. Treats hypertension, pre anesthetic

Question 2

Apraclonidine

Answer 2

Reduces intraocular pressure. Treats glaucoma. Decrease aqueous humor production

Question 3

Xylazine

Answer 3

Receptor in the locus coeruleus of brainstem and spinal cord. Produces sedation in large animals. Anaesthetic premedication

Question 4

Detomidine

Answer 4

Sedative with analgesic action. Sedation in large animals. Can be combined with butorphanol and ketamine

Question 5

Medetomidine

Answer 5

Sedative with analgesic in small animals and horses. Treats emergence delirium following anaesthesia.

Question 6

Dexmedetomidine

Answer 6

Twice as potent for small animals

Question 7

Romifidine

Answer 7

IVsedation in horses.

Question 8

Methyl dopa

Answer 8

Antihypertensive agent. Competitive inhibitor of DOPA decarboxylase. Metabolized alpha methyl NE in brain. Lowers blood pressure.