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Enf. Inflamatorias (GOTA & ARTRITIS REUMATOIDE) > Alopurinol > Flashcards

Alopurinol Flashcards

1
Q

Mecanismo de Acción

A

Inhibe de manera competitiva a la enzima Xantina Oxidasa

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2
Q

Función de Xantina Oxidasa

A

Oxidación de hipoxantina a xantina y de xantina a ácido úrico

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3
Q

Vía de administración

A

Oral

Intravenosa

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4
Q

Biodisponibilidad

A

80-90%

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5
Q

Metabolismo

A

Hepático

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6
Q

Metabolito activo

A

Oxipurinol

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7
Q

Eliminación

A

Renal - orina

Biliar - heces

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8
Q

Indicaciones Terapéuticas

A

Hiperuricemia en Px con GOTA

Profilaxis de hiperuricemia en px con neoplasias hematológicas

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9
Q

Interacciones

A

Aumenta la semivida de probenecid

Probenecid aumenta la depuración del oxipurinol

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10
Q

Contraindicaciones

A

Hipersensibilidad

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11
Q

Reacciones Adversas

A 
Erupción maculopapular
Prurito
Leucopenia transitoria
Leucocitosis
Eosinofilia
Hepatomegalia
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Enf. Inflamatorias (GOTA & ARTRITIS REUMATOIDE) (11 decks)

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