ALLOSTERIC REGULATION OF ENZYMES IN RESPONSE TO CELLULAR ENERGY STATUS Flashcards

1
Q

Low Cellular Energy: ↑ AMP, ↓ ATP, ↓ citrate, ↓ acetyl-CoA: Regulated Enzyme?

A

↑ Phosphofructokinase

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2
Q

Low Cellular Energy: ↑ AMP, ↓ ATP, ↓ citrate, ↓ acetyl-CoA: Metabolic Response?

A

↑ Glycolysis

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3
Q

Low Cellular Energy: ↓ ATP, ↓ acetyl-CoA: Regulated Enzyme?

A

↑ Pyruvate kinase

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4
Q

Low Cellular Energy: ↑ ADP, ↑ pyruvate: Regulated Enzyme?

A

↑ Pyruvate dehydrogenase

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5
Q

Low Cellular Energy: ↓ ATP, ↓ acetyl-CoA: Metabolic Response?

A

↑ TCA cycle

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6
Q

Low Cellular Energy: ↑ ADP: Regulated Enzyme?

A

↑ Isocitrate dehydrogenase

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7
Q

Low Cellular Energy: ↑ AMP: Regulated Enzyme?

A

↓ Fructose-1,6-bisphosphatase

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8
Q

Low Cellular Energy: ↑ AMP: Metabolic Response?

A

↓ Gluconeogenesis

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9
Q

Low Cellular Energy: ↓ Malonyl-CoA: Regulated Enzyme?

A

↑ Carnitine acyltransferase I

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10
Q

Low Cellular Energy: ↓ Malonyl-CoA: Metabolic Response?

A

↑ Fatty acid β-oxidation

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11
Q

Abundant Cellular Energy: ↑ ATP, ↑ citrate: Regulated Enzyme?

A

↓ Phosphofructokinase

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12
Q

Abundant Cellular Energy: ↑ ATP, ↑ citrate: Metabolic Response?

A

↓ Glycolysis

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13
Q

Abundant Cellular Energy: ↑ ATP: Regulated Enzyme?

A

↓ Isocitrate dehydrogenase

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14
Q

Abundant Cellular Energy: ↑ ATP: Metabolic Response?

A

↓ TCA cycle

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15
Q

Abundant Cellular Energy: ↑ ATP: Regulated Enzyme?

A

↓ α-Ketoglutarate dehydrogenase

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16
Q

Abundant Cellular Energy: ↑ Acetyl-CoA: Regulated Enzymes?

A

↑ Pyruvate carboxylase

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17
Q

Abundant Cellular Energy: ↑ Acetyl-CoA: Metabolic Response?

A

↑ Gluconeogenesis

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18
Q

Abundant Cellular Energy: ↑ Citrate: Regulated Enzyme?

A

↑ Fructose-1,6-bisphosphatase

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19
Q

Abundant Cellular Energy: ↑ Citrate: Regulated Enzyme?

A

↑ Acetyl-CoA carboxylase

20
Q

Abundant Cellular Energy: ↑ Citrate: Metabolic Response?

A

↑ Fatty acid synthesis

21
Q

Abundant Cellular Energy: ↑ Malonyl-CoA: Regulated Enzyme?

A

↓ Carnitine acyltransferase I

22
Q

Insulin: Gluconeogenesis

A

Decrease in the liver

23
Q

Glucagon: Gluconeogenesis

A

Increase in the liver

24
Q

Glucagon: Glycogenolysis

A

Increase in the liver

25
Q

Epinephrine: Glycogenolysis

A

Increase in the liver and skeletal muscle

26
Q

Insulin: Glycogenesis

A

Increase in the liver and skeletal muscle

27
Q

Glucagon: Glycogenesis

A

Decrease in the liver

28
Q

Epinephrine: Glycogenesis

A

Decrease in the liver and skeletal muscle

29
Q

Insulin: Glycolysis

A

Increase in the liver and skeletal muscle

30
Q

Glucagon: Glycolysis

A

Decrease in the liver

31
Q

Epinephrine: Glycolysis

A

Increase in the skeletal muscle

32
Q

Insulin: Glucose uptake by GLUT4

A

Increase in the liver, heart, and skeletal muscle

33
Q

Glucagon: Fatty Acid Oxidation

A

Increase in the liver

34
Q

Insulin: Fatty Acid Synthesis

A

Increase in the adipose tissue, skeletal muscle, and the liver

35
Q

Glucagon: Fatty Acid Synthesis

A

Decrease in adipose tissue and the liver

36
Q

Epinephrine: Fatty Acid Synthesis

A

Decrease in the adipose tissue, skeletal muscle, and the liver

37
Q

Insulin: Fatty acid uptake from plasma lipoproteins

A

Decrease in the skeletal muscle and adipose tissue

38
Q

Epinephrine: Fatty acid uptake from plasma lipoproteins

A

Increase in the skeletal muscle

39
Q

Insulin: Triacylglycerol Synthesis

A

Increase in the adipose tissue

40
Q

Glucagon: Triacylglycerol Synthesis

A

Decrease in the liver

41
Q

Insulin: Triacylglycerol Breakdown (Lipolysis)

A

Decrease in the adipose tissue

42
Q

Glucagon: Triacylglycerol Breakdown (Lipolysis)

A

Increase in the adipose tissue

43
Q

Epinephrine: Triacylglycerol Breakdown (Lipolysis)

A

Increase in the adipose tissue and the skeletal muscle

44
Q

Insulin: Protein Synthesis (Translation)

A

Increase in the skeletal muscle and the liver

45
Q

Insulin: Protein Breakdown (Proteolysis)

A

Decrease in the skeletal muscle

46
Q

Glucagon: Ketone Body Production

A

Increase in the liver