Allergy/Immunology

Question 1

Angiooedema effect on mast cell typtase?

Answer 1

It does not cause a rise

Question 2

When does ACEi induced angiooedema usually occur?

Answer 2

Usually within one week but can be as long as 1.8 YEARS!

Question 3

Pts with heredity angio oedema are at increased risk of which AI disease?

Answer 3

SLE

Note: If treatment fails to normalise the C4 levels and they remain persistently low; these patients are at an increased risk of developing SLE

Question 4

Risk factors for allopurinol hypersensitivity syndrome?

Answer 4

Renal impairment
thiazide diuretic use
recent initiation of allopurinol (weeks/months).

Note: features are renal and hepatic dysfunction, eosinophilia, vasculitis and mortality is 20-25%

Question 5

What is Jarisch-Herxheimer reaction?

Answer 5

Acute febrile illness with headache, myalgia, chills and rigors starting within 12 hours of the first dose of treatment (usually for syphilis) and resolving within 24 hours.