allergy and immunology p 47 - 54

Question 1

what is another term for “anaphylaxis?”

Answer 1

immediate hypersensitivity

Question 2

what is the most important cause of anaphylaxis in health care workers?

Answer 2

latex

Question 3

what do you call the localized anaphylaxis with “wheal and flare?”

Answer 3

urticaria

Question 4

name 3 hallmark symptoms of anaphylaxis?

Answer 4

rash, hypotension, respiratory symptoms (shortness of breath, wheezing, swelling of lips, tongue, stridor)

Question 5

what are the best initial therapy for anaphylaxis?

Answer 5

epinephrine, antihistamines such as diphenhydramine (H1 blocker), glucocorticouds, emergent airway protection

Question 6

a 2 y/o female comes in for freq. infection with low B cell count but normal T cells, what is the dx?

Answer 6

common variable immunodeficiency (CVID)

Question 7

3 y/o male comes in for frequent infection with low B cell count but normal T cells, what is the dx?

Answer 7

X-linked (Bruton) agammaglobulinemia

Question 8

name the 4 clinical hallmarks of Wiskott-Aldrich syndrome

Answer 8

normal T-cells
normal B-cells
low platelet
eczema

Question 9

2 clinical hallmarks for IgA def?

Answer 9

atopic dz, anaphylaxis upon blood transfusion

Question 10

2 dx tests for chronic granulomatous disease?

Answer 10

nitroblue tetrazolium testing

dihydrorhodamine 123 (DHR) test

Question 11

what is the hallmark clinical sx of chronic granulomatous dz?

Answer 11

lymph nodes with purulent material leaking out

Question 12

name 4 microbes associated with chronic granulomatous dz

Answer 12

staph, burkholderia, nocardia, aspergillus

catalase positive organisms

Question 13

dx? a young female comes in with freq skin infection with staph

Answer 13

hyper IgE syndrome

Question 14

5 symptoms of IgA def

Answer 14

sinopulmonary infections, atopic dz, anaphylaxis to blood transfusion, spruelike condition with fat malabsorption, inc risk of vitiligo, thyroiditis, and rheumatoid arthritis

Question 15

dx?

6 month old boy comes in with recurrent sinopulmonary infection and PCP, Candida infections which you would expect to see in HIV pts

Answer 15

severe combined immunodef

Question 16

dx?

a male child comes in with freq sinopulmonary infections. physical exam shows dec size of tonsils, adenoids, lymph nodes, and spleen, but T cell counts are normal

Answer 16

X-linked (Bruton) agammabulinemia

Question 17

dx?

20 y/o male comes in with freq sinopulmonary infections with symptoms of bronchitis, pneumonia, sinusitis, and otitis media, further exam reveals infection of Giardiasis, spruelike intestinal malabsorption

Answer 17

common variable immunodef

Question 18

common variable immunodef pts are vulnerable to what kind of malignancy?

Answer 18

lymphoma

Question 19

in allergic rhinitis pt, what will you see in their nasal smear?

Answer 19

inc number of eosinophils