Allergy and angioedema

Question 1

Which antihistamines can be used (IV) as adjunct to adrenaline in anaphylaxis
(2 points)

Answer 1

Chlorphenamine (may also be given IM)
Promethazine

Give after adrenaline

Question 2

Which medicinal products are most associated with anaphylaxis?
(4 points)

Answer 2

Blood products
Vaccines
NSAIDs (including aspirin)
Antibacterials (e.g. penicillins)

Question 3

Adrenaline doses:

a) Children < 5
b) Children 6-11
c) Children (12+) and Adults

Answer 3

a) 150 mcg (0.15 mL)
b) 300 mcg (0.3 mL)
c) 500 mcg (0.5mL)

Note: quantities in mL are using a 1 mg/mL injection

Question 4

Why are second generation antihistamines less sedating?

Answer 4

They do not cross the BBB