Allergy Flashcards
1
Q
What is Serum Sickness? What drugs are classic?
A
The most common symptoms of serum sickness are rash, fever, malaise, and polyarthralgias or polyarthritis, which occur one to two weeks after first exposure to the responsible agent and resolve within a few weeks of discontinuing the drug. In patients who have been previously exposed to the agent, the syndrome starts earlier (ie, within one to seven days of receiving the inciting agent), and the illness has a more severe and “explosive” onset. The rash is a pruritic urticarial and/or morbilliform eruption.
Drugs:
ATG, rituximab, and infliximab, have been implicated. SSLRs are most commonly caused by antibiotics, such as penicillin, cefaclor, amoxicillin, and trimethoprim-sulfamethoxazole
