Allergies Flashcards
1
Q
Serum sickness
-common agents
A
- fever, malaise, LAD
- arthralgia, urticaria, morbilliform skin eruptions
- ceph, anti venom
2
Q
Drug fever (infection vs inflammation vs drug)
- CNS
- direct effects on tissues
- name the two patterns of fever
- common agents
A
- IL-1 and TNF cause fever
- chemo, tumor cell destruction, fever
- low and continuous, spiking and intermittent
- Amp B, ABX
3
Q
Jarisch-Herxheimer Rxn (JHR)
- symptoms
- due to, time frame
- louse borne relapsing fever (LBRF) Tx
- tick borne (TBRF) Tx
- other causes
A
- rigors, fever, hypotension (kinda like SERS)
- ABX for a number of spirochetes, release of bacterial components (HOUSE), within hours
- tetra, doxy, or Pen G
- tetra, doxy, pen G, erythro, or ceftriaxone
- secondary and tertiary syphilis and brucellosis, schistosomiasis, trypanosomiasis
4
Q
SLE
- drug type
- manifestations
A
- hydrazine or amin group, procainamide, hydralazine, isoniazid, phenytoin (HIPP)
- fever, malaise, rash, arthralgias ,mucosal ulcers, pulm.
5
Q
interstitial nephritis (INs)
- manifestations
- humoral MOA
- cell mediated
- common agents
A
- fever, rash, eosinophilia, hematuria, proteinuria, eosinophiluria
- antibody to a drug BM complex
- antistaphylococal PCNs, cimetidine, sulfonamides
6
Q
hepatic HS/toxic hepatitis
- eosinophilia (NAACP)
- common agents
A
- rxn to drug or metabolite
- neoplasm, asthma, allergy, CT, parasites
- erythro, PCNs
7
Q
vasculitis
- hallmark sign
- where
A
- palpable purpuric lesion
- usually in the extremities
8
Q
maculopapular or morbilliform rash
- what is spared
- common agents
A
- symmetrical, flat, red
- palms and soles-spared
- pcns, abx, anticonvulsants
9
Q
urticaria, angioedema
- where is angioedema?
- agents
A
- histamine, blood plasma leaks
- pruritic
- in the face
- abx, nsaids, anticonvulsants (phenytoin)
10
Q
fixed drug eruptions
A
- dark red, violet
- abx, pcn, tcn, cipro, bactrim
- nsaids, quinidine, sulfonamides
11
Q
phototoxicity/photoallergy
A
- immediately after tx and light exposure
- uv light + tissue dmg
- tcns, carbamazepine, griseofulvin, coal tar, oral contraceptives
12
Q
eczematous contact dermatitis
A
- during topic treatment of a preexisting dermatitis
- sulfodine, zinc ointment
13
Q
ertythema multiforme
A
- bullseye lesion
- aspirin
- sulfas
14
Q
SJS
A
- high fever, muscle and joint aches
- involves conjuctiva, can cause blindness
- anticonvulsant, bactrim
- tx like a burn patient!!!!
15
Q
TEN
A
- large flaccid bullae
- abx, anticonvulsants, nsaids
