Allergic Rhinitis

Question 1

Allergic Rhinitis – Symptoms

Answer 1

Nasal pruritus
Sneezing
Rhinorrhea
Nasal congestion

Question 2

Allergic Rhinitis – Cause

Answer 2

Response to localized IgE-mediated inflammation that is triggered by an aeroallergen to which the individual is sensitized

Question 3

Allergic Rhinitis – Types

Answer 3

3 types:

1) Perennial: house dust mites, pets, molds
2) Seasonal: pollens
3) Occupational: mice for lab workers, chemicals

Question 4

Allergic Rhinitis – Prevalence

Answer 4

• 40% of people globally

* 82m people in the US suffer from allergic rhinitis (~20m with hay fever)

Question 5

Allergic Rhinitis – Treatments

Answer 5

• Immunotherapy (SLIT, allergy shots)
   >> ALK’s Grastek for grass pollen and Ragwitek for ragweed
   >> Stallergenes’ Oralair for grass pollen
• Anti-histamines
   >> Merck’s Claritin
• Decongestants
• Leukotriene Receptor Antagonists
   >> Merck’s Singulair (montelukast)
• Corticosteroids
   >> Merck’s Nasonex
   >> AZ’s Rhinocort

Question 6

Allergic Rhinitis - Market Size

Answer 6

~$15B global market