All Questions Flashcards
1
Q
Define Biotech
A
- application of science and technology
- to living organisms (and parts)
- to alter living and non living material
- for the production of knowledge, goods and services
2
Q
How is biotech different from other disciplines?
A
- long product development cycles
- high biological/scientific risk
- high infrastructure requirements
- skilled personell required
- high funding need
- highly regulated environment
3
Q
Steps in individualized vaccine manufacturing
A
- take blood sample
- mapping of mutations
- Neo antigen prediction
- On-demand RNA manufacturing
- Individualized immunotherapy
4
Q
Important Steps in biotech’s way to IPO
A
- Incubation phase
- Plattform expansion and early clinical phase
- IPO (2019)
5
Q
Joint Venture
A
One partner brings tech, the other financing and expertise
Partner 1:
- Funding
- Expertise
- Clinical Development
Partner 2:
- RNA intellectual property
6
Q
Traditional drug discovery process
A
- Drug discovery
- Pre clinical (3-6 years)
- Clinical trials (6-7 years)
- FDA review (0,5 -2 years)
- LG Scale MFG
7
Q
FIPCO & FIPNET
A
- FIPCO: Fully integrated pharmaceutical company
- all in house
- FIPNET: Fully integrated pharmaceutical network
- some things outsourced
8
Q
Ways of financing a Pharma company
A
- Series: get investors into company (but get diluted)
- Collaboration: A buys the work (compound) of B. B receives royalties for sold products
- Joint Venture: one partner brings financing, the other tech
9
Q
Case Study
A
- Out licensing didn’t work. Biontech doesn’t want to sell the whole mRNA platform and partner doesn’t want a piece only (one indication like bladder cancer
- Joint venture too complex
–> Collaboration: Cost/profit sharing model. (Similar to JV but simpler) - Deal parameters:
- 50:50 cost sharing
- right to co-promote
- Biotech responsible for clinical manufacturing with the right to manufacture commercial within global supply network
10
Q
Proceeds
A
the amount of money you want to collect from investors
11
Q
Dilution
A
You don’t want to get diluted, so you try to get a high pre money valuation
- You get more capital for the same amount of shares
12
Q
IPO vs private
A
- Valuation is known and determined by market
- many investors vs few
- accelerated in a public market
13
Q
Benefits of Series investing before IPO
A
- You can negotiate about value of shares
- max. 10 investors
14
Q
Benefits of IPO
A
- much faster to get new funds
15
Q
Why Biotech needs to go public
A
because they burn money for the first years
