All of Units 1 & 2 - Higher Human Biology Hodder Gibson Glossary Flashcards
Learn the Glossary term meaning and spelling in the How to Pass Higher Human Biology book from Hodder Gibson
Cancer cell
(1.1) cell that grows and divides in an unregulated way to produce a tumour
Differentiation
(1.1) changes to cells that allow them to specialise for different functions
Diploid
(1.1) refers to a cell having two matching sets of chromosomes
Embryonic stem cells
(1.1) stem cells from embryos that can divide and become any type of cell
Ethical issue
(1.1) issue affecting human attitudes and decisions regarding various choices
Germline cell
(1.1) cell that can give rise to gametes
Haploid
(1.1) describes a cell having one set of chromosomes (e.g. gametes)
Lymphocyte
(1.1) type of white blood cell involved in a specific immune response
Meiosis
(1.1) type of cell division resulting in four haploid gametes
Mitosis
(1.1) division of the nucleus of somatic or germline cells, giving two diploid daughter cells
Multipotent stem cell
(1.1) stem cell that has the potential to make almost all cell types found within a particular tissue
Phagocyte
(1.1) white blood cel that can surround, engulf and digest foreign material and pathogens
Pluripotent stem cell
(1.1) stem cell that has the potential to make almost all differentiated cell types of the body
Red blood cell
(1.1) blood cell containing haemoglobin, which can carry oxygen in the bloodstream
Regulatory signal
(1.1) molecular signal that can be received by a cell to modify its activity
Secondary tumour
(1.1) cancer formed from a cell transported from a primary tumour
Somatic cell
(1.1) body cell that divides by mitosis to form more body cells
Stem cell
(1.1) unspecialised cell that can divide and then differentiate
Therapeutic
(1.1) used as part of a medical therapy
Tissue stem cells
(1.1) stem cell from issue that divide and differentiate to become cells of that tissue
Tumour
(1.1) collection of cancer cells produced by excessive, uncontrolled cell division
3’-5’
(1.2) strand of nucleic acid running from a sugar to a phosphate
Adenine (A)
(1.2) DNA base that pairs with thymine
Amplification of DNA
(1.2) the production of multiple copies of a sequence of DNA; repeated copying of a piece of DNA
Antiparallel
(1.2) parallelstrands in DNA that run in opposite directions in terms of chemical polarity
ATP
(1.2) adenosine triphosphate; molecule used for energy transfer in cells
Base
(1.2) nitrogenous substance that is a component of DNA nucleotides
Cytosine (C)
(1.2) DNA base that pairs with guanine
Deoxyribose
(1.2) pentose sugar that is a component of DNA nucleotides
DNA
(1.2) deoxyribonucleic acid; molecule that holds the genetic code in living organisms
DNA polymerase
(1.2) enzyme that adds free nucleotides during DNA replication
Double helix
(1.2) three-dimensional shape of a DNA molecule
Fragments
(1.2) replicated sequences of the lagging strand which are later joined by ligase
Gal electrophoresis
(1.2) laboratory method used to separate mixtures of DNA, RNA or proteins according to molecular size
Guanine (G)
(1.2) DNA base that pairs with cytosine
Heat-tolerant DNA polymerase
(1.2) enzyme from hot-spring bacteria, used in PCR
Hydrogen bond
(1.2) weak chemical link joining complementary base pairs in DNA
Lagging strand
(1.2) DNA strand that is replicated in fragments
Leading strand
(1.2) DNA strand that is replicated continuously
Ligase
(1.2) enzyme that joins DNA fragments
Nucleotide
(1.2) component of DNA consisting of a deoxyribose sugar, a phosphate group and a base
Phosphate
(1.2) component of DNA nucleotide
Polymerase chain reaction (PCR)
(1.2) method of amplifying sequences of DNA in vitro
Primer
(1.2) short complementary strand of DNA
Replication
(1.2) formation of copies of DNA molecules
Sugar-phosphate backbone
(1.2) strongly bonded strand of DNA
Target sequences
(1.2) complementary sequence of bases on the 3’ end ofDNA to which primer attaches
Template strand
(1.2) DNA strand on which a complementary copy is made
Thymine (T)
(1.2) DNA base that pairs with adenine
Alternative RNA splicing
(1.3) particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA)
Amino acid
(1.3) unit of polypeptide structure
Anticodon
(1.3) sequence of three bases on tRNA that codes for a specific amino acid
Attachment site
(1.3) site on a transfer RNA molecule to which a specific amino acid binds
Codon
(1.3) sequence of three bases on mRNA that codes for a specific amino acid
Environmental factors
(1.3) factors such as diet, light and temperature that can interact with an organism’s genotype to affect its phenotype
Exon
(1.3) coding sequence of DNA
Gene
(1.3) section of DNA that codes for a protein
Gene expression
(1.3) transcription and translation of a gene to synthesise proteins
Interactions
(1.3) chemical attractions and bonding such as hydrogen bonds between amino acids giving proteins their three-dimensional shape
Intron
(1.3) non-coding sequence of DNA
Mature transcript
(1.3) RNA transcript that has been spliced and processed ready for translation
Messenger RNA (mRNA)
(1.3) carries a copy of the DNA code from nucleus to ribosome
Peptide bond
(1.3) strong chemical link between amino acids in the primary structure of a polypeptide
Phenotype
(1.3) outward appearance of an organism
Polypeptide
(1.3) short strand of amino acids
Primary transcript
(1.3) molecule made when DNA is transcribed
Ribose
(1.3) sugar that forms part of an RNA nucleotide
Ribosomal RNA (rRNA)
(1.3) type of RNA that makes up ribosomes
Ribosome
(1.3) site of protein synthesis; composed of rRNA and protein
RNA
(1.3) ribonucleic acid; several forms of single-stranded nucleic acid that are involved in protein synthesis
RNA polymerase
(1.3) enzyme which unwinds and unzips DNA and adds complementary nucleotides to form a primary transcript
RNA splicing
(1.3) joining of exons following the removal of introns from a primary transcript
Start codon
(1.3) first codon of a messenger RNA (mRNA) transcript translated by a ribosome
Stop codon
(1.3) codon within messenger RNA that signals a termination of translation into proteins
Transcription
(1.3) copying of DNA sequences to make a primary transcript
Transfer RNA (tRNA)
(1.3) transfers specific amino acids to the mRNA on the ribosomes
Translation
(1.3) production of a polypeptide at a ribosome using information encoded in mRNA
Uracil (U)
(1.3) RNA base not found in DNA; pairs with adenine in transcription and translation
Chromosome
(1.4) rod-lke structure that contains the genetic material of an organism encoded into DNA
Deletion (of genes)
(1.4) chromosome mutation in which a sequence of genes is lost from a chromosome
Deletion (of nucleotides)
(1.4) single gene mutation involving removal of a nucleotide from a sequence
Duplication
(1.4) chromosome mutation in which a section of chromosome is added from its homologous partner
Frame-shift mutation
(1.4) gene mutation in which all amino acids coded for after the mutation are affected
Insertion
(1.4) single gene mutation in which an additional nucleotide is placed into a sequence
Inversion
(1.4) chromosome mutation in which a set of genes rotates through 180°
Missense
(1.4) substitution mutation; a single nucleotide change results in a codon for a different amino acid
Mutation
(1.4) changes in the DNA that can result in absence of protein or synthesis of an altered protein
Nonsense
(1.4) substitution mutation in which a codon is changed to a stop codon, shortening the resulting protein
Protein
(1.4) large molecule made up of chains of amino acids linked by peptide bonds
Single gene mutations
(1.4) alteration of a DNA nucleotide sequence as a result of the substitution insertion or deletion of nucleotides
Splice-site mutation
(1.4) mutation at a point where coding and non-coding regions meet in a section of DNA
Substitution
(1.4) single gene mutation in which one nucleotide is replaced by another
Translocation
(1.4) chromosome mutation in which part of a chromosome becomes attached to another
Bioinformatics
(1.5) use of computers and statistics in analysis of sequence data
Genome
(1.5) total genetic material present in an organism
Genomic sequencing
(1.5) the process of determining the sequence of nucleotide bases for individual genes or entire genomes
Non-coding
(1.5) sequences of DNA that do not code for proteins, including those that are transcribed but not translated and sequences that are involved in gene regulation
Personalised medicine
(1.5) development in which treatment is based on an individuals genome
Pharmacogenetics
(1.5) the study of inherited differences that affect metabolic pathways which can influence individual therapeutic responses to, and side-effects of, drugs
Sequence data
(1.5) information concerning amino acid or nucleotide base sequences of a gene or
Activation energy
(1.6) input of energy required to start a chemical reaction
Active site
(1.6) region on an enzyme molecule where the substrate binds
Affinity
(1.6) attraction between the active site of an enzyme and its substrate
Anabolic reactions
(1.6) reactions which build up larger molecules from small molecules and which require energy
Catabolic reactions
(1.6) reactions which break down large molecules into smaller molecules and which release energy
Competitive inhibition
(1.6) slowing of reaction rate due to the presence of a substance resembling the substrate
End-product
(1.6) the final product of a series of reactions with enzymes in a metabolic pathway
Feedback inhibition
(1.6) enzyme inhibition caused by the presence of an end product of a metabolic pathway
Induced fit
(1.6) change to an enzyme’s active site brought about by its substrate
Metabolic pathway
(1.6) enzyme-catalysed sequence of chemical reactions in a cell
Metabolism
(1.6) the sum total of all the chemical reactions that take place in cells
Non-competitive inhibition
(1.6) enzyme inhibition by a substance that permanently alters the active site of the enzyme
Product
(1.6) substance resulting from an enzyme-catalysed reaction
Substrate
(1.6) substance on which an enzyme works
Acetyl coenzyme A
(1.7) molecule that transfers the acetyl group to the citric acid cycle
Acetvi group
(1.7) produced by breakdown of pyruvate, joins with oxaloacetate in the citric acid cycle
ATP synthase
(1.7) membrane-bound enzyme that synthesises ATP
Cellular respiration
(1.7) release of energy from respiratory substrates
Citrate
(1.7) citric acid; first substance produced in the citric acid cycle
Citric acid cycle
(1.7) second stage of aerobic respiration occurring in the matrix of mitochondria
Coenzyme A
(1.7) substance that carries acetyl groups into the citric acid cycle
Dehydrogenase
(1.7) enzymes that remove hydrogen from their substrates; important in the citric acid cycle
Electron transport chain
(1.7) group of proteins embedded in membranes of mitochondria and chloroplasts
Electrons
(1.7) negatively charged particles that yield energy as they pass through an electron transport chain
Energy investment phase
(1.7) the phosphorylation of intermediates in glycolysis, which uses two molecules of ATP in the first stage of glycolysis
Energy pay-off stage
(1.7) the second stage of glycolysis, which leads to the generation of more ATP
Glucose
(1.7) sugar that is the main respiratory substrate in cells
Glycolysis
(1.7) first stage in cellular respiration
Hydrogen ion
(1.7) an atom of hydrogen that has lost an electron leaving a positively charged proton (symbol: H*)
Intermediate
(1.7) substance in a metabolic pathway between the original substrate and the end product
Matrix
(1.7) central cavity of a mitochondrion in which the citric acid cycle occurs
Mitochondrion
(1.7) cell organelle in which the aerobic stages of respiration occur (plural: mitochondria)
NAD
(1.7) coenzyme which carries hydrogen and electrons from glycolysis and the citric acid cycle to the electron transport chain
Net gain
(1.7) overall gain of ATP during glycolysis
Oxaloacetate
(1.7) substance that combines with the acetyl group in the citric acid cycle to form citrate
Phosphorylation
(1.7) addition of phosphate to a substance
Pyruvate
(1.7) the end product of glycolysis
Fast-twitch muscle fibre
(1.8) type of muscle fibre used in short bursts of activity
Glycogen
(1.8) store of glucose in muscle cells and liver
Lactate
(1.8) produced by the fermentation of pyruvate in mammalian muscle cells
Muscle fatigue
(1.8) painful condition caused by the accumulation of lactic acid in muscles
Myoglobin
(1.8) protein in muscle tissue that can bind with oxygen
Oxygen debt
(1.8) builds up during fermentation in muscle cells
Skeletal muscle
(1.8) muscle attached to the skeleton that brings about locomotion
Slow-twitch muscle fibre
(1.8) type of muscle fibre used in endurance activities
Corpus luteum
(2.1) formed from a follicle after ovulation: produces progesterone
Follicle
(2.1) cluster of cells in the ovary that protects the developing ovum and secretes hormones
Gametes
(2.1) sex cells containing the haploid chromosome number
Interstitial cells
(2.1) cells in testes found between the seminiferous tubules; produce testosterone
Oestrogen
(2.1) hormone produced by the ovary that helps in the repair and thickening of the endometrium after menstruation
Ovaries
(2.1) female sex organs in which ova are produced
Oviduct
(2.1) fine tube connecting an ovary to the uterus; location of fertilisation
Progesterone
(2.1) hormone produced by the ovary that thickens and vascularises the endometrium
Prostate gland
(2.1) produces fluid that makes up part of the semen
Seminal vesicles
(2.1) glands producing fluid that forms part of the semen
Seminiferous tubules
(2.1) very narrow tubes in the testes in which sperm cells are produced
Testes
(2.1) male sex organs responsible for the production of sperm
Testosterone
(2.1) hormone produced by interstitial cells
Zygote
(2.1) fertilised egg cell
Endocrine gland
(2.2) gland that produces and releases hormones
Endometrium
(2.2) inner lining of the uterus
Follicle stimulating hormone (FSH)
(2.2) pituitary hormone that controls development of follicles in ovaries and sperm production in males
Follicular phase
(2.2) first stage in the menstrual cycle during which a follicle develops
Hormone
(2.2) protein released by an endocrine gland into the blood that acts as a chemical messenger
Hypothalamus
(2.2) region of the mammalian brain that secretes releaser hormone at puberty
Interstitial cell stimulating hormone (ISH)
(2.2) hormone from the pituitary gland that stimulates testosterone production by the interstitial cells
Luteal phase
(2.2) second stage of the menstrual cycle in which a corpus lureum is present
Luceinising hormone (LH)
(2.2) pituitary hormone that triggers ovulation and corpus luteum development
Menstrual cycle
(2.2) approximately 28-day cycle in the middle of which ovulation occurs
Menstruation
(2.2) removal of the endometrium and an unfertilised egg cell at the end of a menstrual cycle
Negative feedback
(2.2) system of maintaining a steady state in various body systems
Pituitary gland
(2.2) gland in the brain that releases many hormones
Releaser hormone
(2.2) hormone which affects the pituitary gland to trigger puberty
Vascularisation
(2.2) when body tissue develops capillaries
Artificial insemination (Al)
(2.3) insertion of donated sperm directly into the uterus
Continuous fertility
(2.3) males secrete a steady level of testosterone and produce a steady quantity of sperm continuously after puberty
Contraception
(2.3) the intentional prevention of pregnancy (conception) by natural or artificial methods independent variable
Cyclical fertility
(2.3) women are only fertile for a few days during each menstrual cycle
In vitro fertilisation (IVF)
(2.3) medical procedure involving fertilisation of eggs by sperm in laboratory containers
Intracytoplasmic sperm injection (ICSI)
(2.3) injection of sperm directly into an egg during IVF
Pre-implantation genetic diagnosis (PGD)
(2.3) genetic profiling of embryos prior to implantation during fertility treatments
Semen
(2.3) also called seminal fluid; fluid that contains sperm cells
Allele
(2.4) form of a gene coding for a version of a characteristic
Amniocentesis
(2.4) prenatal test to assess health of fetus using cells from amniotic fluid
Anomaly scan
(2.4) antenatal ultrasound scan that checks for physical abnormalities
Antenatal screening
(2.4) use of tests to identify risk of a disorder before birth
Autosomal recessive
(2.4) allele on chromosomes 1-22; expressed in phenotype if the genotype is homozygous for the recessive allele
Autosome
(2.4) chromosome that is not a sex chromosome
Charionic villus sampling (CVS)
(2.4) prenatal test to assess health of the fetus using cells from the
Dating scan
(2.4) antenatal ultrasound scan to determine pregnancy stage and due date
Diagnostic tests
(2.4) tests such as amniocentesis used to confirm if the fetus has a medical condition
Embryo
(2.4) stage of development up to about 8 weeks that leads to the formation of a fetus
False positive result
(2.4) error in reporting in which a test result indicates presence of a condition which is actually absent
Fetus
(2.4) stage of a baby after 8 weeks of development
Heterozygous
(2.4) having two different alleles of the same gene
Homozygous
(2.4) having two identical alleles of the same gene
Incomplete dominance
(2.4) when an allele is not completely masked by a dominant allele, thus affecting an individual’s phenotype
Karyotype
(2.4) display of matched chromosomes produced for medical purposes
Marker chemicals
(2.4) substances produced during pregnancy which are tested for alongside scans
Pedigree chart
(2.4) diagram showing the occurrence of phenotypes of a particular gene in a family tree
Phenylketonuria (PKU)
(2.4) metabolic disorder that is tested for by postnatal screening
Postnatal screening
(2.4) diagnostic testing of newborn babies
Prenatal diagnosis
(2.4) identification of the risk of disorders in unborn babies
Sex-linked recessive
(2.4) recessive allele carried on the X chromosome
Ultrasound scanning
(2.4) diagnostic procedure used for various prenatal checks, such as establishing the stage of pregnancy and the date that the baby is due
Artery
(2.5) blood vessel that carries blood away from the heart
Capillary
(2.5) narow, thin walled blood vessel that exchanges materials with the tissues
Connective tissue
(2.5) type of tissue found between other tissues and often supports other tissues
Endothelium
(2.5) layer of cells that lines the inner surface of blood vessels
Lumen
(2.5) central channel of a tube such as a blood vessel
Lymph fluid
(2.5) fluid made up from issue fluid collected into lymph vessels which circulates the body
Lymph vessels
(2.5) tiny vessels in which lymph circulates around the body
Plasma
(2.5) liquid component of the blood
Pressure filtration
(2.5) passage of molecules through membranes under pressure
Smooth muscle
(2.5) muscle tissue which can contract involuntarily
Tissue fluid
(2.5) Fluid which bathes cells in tissues; derived from blood
Vasoconstriction
(2.5) narrowing of blood vessels to reduce blood flow
Vasodilation
(2.5) widening of blood vessels to increase blood flow
Vein
(2.5) blood vessel with valves that transports blood back to the heart
120/80 mmHs
(2.6) typical blood pressure reading for a young adult
Acetylcholine
(2.6) neurotransmitter released by parasympathetic nerve fibres
Antagonistic
(2.6) opposing actions of the sympathetic and parasympathetic systems
Atrial diastole
(2.6) part of the cardiac cycle in which the heart muscle of the atria relaxes
Atrial systole
(2.6) part of the cardiac cycle in which the heart muscle of the atria contracts Atrio-ventricular (AV) valve
Atrio-ventricular (AV) valve
(2.6) heart valve found between the atria and the ventricles
Atrio-ventricular node (AVN)
(2.6) nervous tissue found at the junction between the atria and the ventricles
Auto-rhythmic cells
(2.6) cells in the SAN which set the rate at which the heart contracts
Autosomal dominant
(2.4) allele on chromosomes 1-22; always expressed in phenotype
Cardiac muscle
(2.6) muscle that makes up the heart walls
Cardiac cycle
(2.6) contraction and relaxation of the heart muscle in a heartbeat
Cardiac output
(2.6) volume of blood expelled from one ventricle of the heart per minute
Coronary heart disease (CHD)
(2.6) condition caused by blockage of coronary arteries of information between them
Deoxygenated blood
(2.6) blood, usually in veins, that carries little oxygen
Diastole
(2.6) part of the cardiac cycle during which cardiac muscle is relaxed
Electrocardiogram (ECG)
(2.6) record of electrical activity in the heart; used to detect abnormalities
Hypertension
(2.6) abnormally high blood pressure in arteries
Medulla
(2.6) part of the brain with centres controlling breathing, heart rate and peristalsis
Noradrenaline
(2.6) hormone and neurotransmitter
Oxygenated blood
(2.6) blood containing a high level of oxygen
Parasympathetic nerves
(2.6) nerve fibres which result in a decrease in heart rate; part of the autonomic nervous system (ANS)
Semi-lunar (SL) valves
(2.6) valves leading into the main arteries leaving the heart
Sino atrial node (SAN)
(2.6) region of nervous tissue in the wall of the right atrium; receives impulses from the medulla
Sphygmomanometer
(2.6) instrument used to measure blood pressure
Stroke volume
(2.6) volume of blood expelled from the left ventricle during one cardiac cycle
Sympathetic (accelerator) nerve
(2.6) nerve fibre that stimulates an increase in heart rate; part of the autonomic nervous system (ANS)
Systole
(2.6) part of the cardiac cycle in which cardiac muscle is contracted
Ventricular diastole
(2.6) part of the cardiac cycle in which the cardiac muscle of the ventricles relaxes
Ventricular systole
(2.6) part of the cardiac cycle in which the cardiac muscle of the ventricles contracts
Angina
(2.7) chest pain occurring when blood supply to heart muscle is restricted
Acheroma
(2.7) swelling on inner wall of artery made up of fatty material and connective tissue
Atherosclerosis
(2.7) potentially serious condition in which acheromas clog the arteries
Cardiovascular diseases (CVD)
(2.7) diseases affecting the heart and circulation
Cholesterol
(2.7) lipid molecule needed for cell membranes and in synthesising steroid hormones
Deep vein thrombosis (DVT)
(2.7) blood clot in a deep vein, often in the leg
Embolus
(2.7) any detached mass of material carried by the circulation
Fibrin
(2.7) protein that helps form a blood clot
Fibrinogen
(2.7) blood protein that is converted to fibrin during the blood clotting process
Heart attack
(2.7) serious medical emergency in which blood supply to the heart muscle is blocked
High-density lipoprotein (HDL)
(2.7) carries excess cholesterol away from body cells and artery surfaces to the liver for elimination
LDL receptor
(2.7) receptor that recognises LDLs and encourages their uptake
Lipoprotein
(2.7) assembly of protein with lipid that enables movement of lipid in water and through membranes
Low density lipoprotein (LDL)
(2.7) carries cholesterol to body cells; if body cells have enough cholesterol, LDL may deposit cholesterol leading to atheroma in arteries
Myocardial infarction (MI)
(2.7) medical term for a heart attack in which blood flow to the heart is reduced
Peripheral vascular disease
(2.7) condition caused by blockage to arteries other than coronary arteries, the aorta or those in the brain
Prothrombin
(2.7) blood component important in clotting it is converted to thrombin during clotting
Pulmonary embolism
(2.7) embolism (blood clot) in the pulmonary circulation
Statins
(2.7) medicine that helps lower LDLs in the blood
Thrombin
(2.7) produced from prothrombin during blood clotting
Thrombosis
(2.7) blood clot within a blood vessel
Adrenal glands
(2.8) glands located above the kidneys which release the hormone adrenaline
Adrenaline
(2.8) hormone that stimulates the release of glucose from glycogen during stress or exercise
Body mass index (BMI)
(2.8) body mass in kilograms/(the square of their height in metres) (Note: This is an approximate measure of whether someone is over- or underweight)
Glucagon
(2.8) hormone produced by the pancreas that stimulates the conversion of glycogen into glucose in the liver
Glucose tolerance test
(2.8) diagnostic test for diabetes in which blood glucose level is measured after drinking a glucose solution
Haemorrhage
(2.8) rupture of blood vessels which may give internal bleeding
Homeostasis
(2.8) maintenance of a steady state in the cells of a living organism
Insulin
(2.8) hormone produced by the pancreas that stimulates the conversion of glucose into glycogen in the liver
Obesity
(2.8) extremely overweight condition; having excess body fat in relation to lean tissue
Type 1 diabetes
(2.8) condition in which an individual is unable to regulate blood sugar level due to a lack of the hormone insulin
Type 2 diabetes
(2.8) condition in which an individual is unable to regulate blood sugar level because cells, especially in the liver, are unresponsive to insulin