All of Units 1 & 2 - Higher Human Biology Hodder Gibson Glossary Flashcards
Learn the Glossary term meaning and spelling in the How to Pass Higher Human Biology book from Hodder Gibson
Cancer cell
(1.1) cell that grows and divides in an unregulated way to produce a tumour
Differentiation
(1.1) changes to cells that allow them to specialise for different functions
Diploid
(1.1) refers to a cell having two matching sets of chromosomes
Embryonic stem cells
(1.1) stem cells from embryos that can divide and become any type of cell
Ethical issue
(1.1) issue affecting human attitudes and decisions regarding various choices
Germline cell
(1.1) cell that can give rise to gametes
Haploid
(1.1) describes a cell having one set of chromosomes (e.g. gametes)
Lymphocyte
(1.1) type of white blood cell involved in a specific immune response
Meiosis
(1.1) type of cell division resulting in four haploid gametes
Mitosis
(1.1) division of the nucleus of somatic or germline cells, giving two diploid daughter cells
Multipotent stem cell
(1.1) stem cell that has the potential to make almost all cell types found within a particular tissue
Phagocyte
(1.1) white blood cel that can surround, engulf and digest foreign material and pathogens
Pluripotent stem cell
(1.1) stem cell that has the potential to make almost all differentiated cell types of the body
Red blood cell
(1.1) blood cell containing haemoglobin, which can carry oxygen in the bloodstream
Regulatory signal
(1.1) molecular signal that can be received by a cell to modify its activity
Secondary tumour
(1.1) cancer formed from a cell transported from a primary tumour
Somatic cell
(1.1) body cell that divides by mitosis to form more body cells
Stem cell
(1.1) unspecialised cell that can divide and then differentiate
Therapeutic
(1.1) used as part of a medical therapy
Tissue stem cells
(1.1) stem cell from issue that divide and differentiate to become cells of that tissue
Tumour
(1.1) collection of cancer cells produced by excessive, uncontrolled cell division
3’-5’
(1.2) strand of nucleic acid running from a sugar to a phosphate
Adenine (A)
(1.2) DNA base that pairs with thymine
Amplification of DNA
(1.2) the production of multiple copies of a sequence of DNA; repeated copying of a piece of DNA
Antiparallel
(1.2) parallelstrands in DNA that run in opposite directions in terms of chemical polarity
ATP
(1.2) adenosine triphosphate; molecule used for energy transfer in cells
Base
(1.2) nitrogenous substance that is a component of DNA nucleotides
Cytosine (C)
(1.2) DNA base that pairs with guanine
Deoxyribose
(1.2) pentose sugar that is a component of DNA nucleotides
DNA
(1.2) deoxyribonucleic acid; molecule that holds the genetic code in living organisms
DNA polymerase
(1.2) enzyme that adds free nucleotides during DNA replication
Double helix
(1.2) three-dimensional shape of a DNA molecule
Fragments
(1.2) replicated sequences of the lagging strand which are later joined by ligase
Gal electrophoresis
(1.2) laboratory method used to separate mixtures of DNA, RNA or proteins according to molecular size
Guanine (G)
(1.2) DNA base that pairs with cytosine
Heat-tolerant DNA polymerase
(1.2) enzyme from hot-spring bacteria, used in PCR
Hydrogen bond
(1.2) weak chemical link joining complementary base pairs in DNA
Lagging strand
(1.2) DNA strand that is replicated in fragments
Leading strand
(1.2) DNA strand that is replicated continuously
Ligase
(1.2) enzyme that joins DNA fragments
Nucleotide
(1.2) component of DNA consisting of a deoxyribose sugar, a phosphate group and a base
Phosphate
(1.2) component of DNA nucleotide
Polymerase chain reaction (PCR)
(1.2) method of amplifying sequences of DNA in vitro
Primer
(1.2) short complementary strand of DNA
Replication
(1.2) formation of copies of DNA molecules
Sugar-phosphate backbone
(1.2) strongly bonded strand of DNA
Target sequences
(1.2) complementary sequence of bases on the 3’ end ofDNA to which primer attaches
Template strand
(1.2) DNA strand on which a complementary copy is made
Thymine (T)
(1.2) DNA base that pairs with adenine
Alternative RNA splicing
(1.3) particular exons of a gene may be included within or excluded from the final, processed messenger RNA (mRNA)
Amino acid
(1.3) unit of polypeptide structure
Anticodon
(1.3) sequence of three bases on tRNA that codes for a specific amino acid
Attachment site
(1.3) site on a transfer RNA molecule to which a specific amino acid binds
Codon
(1.3) sequence of three bases on mRNA that codes for a specific amino acid
Environmental factors
(1.3) factors such as diet, light and temperature that can interact with an organism’s genotype to affect its phenotype
Exon
(1.3) coding sequence of DNA
Gene
(1.3) section of DNA that codes for a protein
Gene expression
(1.3) transcription and translation of a gene to synthesise proteins
Interactions
(1.3) chemical attractions and bonding such as hydrogen bonds between amino acids giving proteins their three-dimensional shape
Intron
(1.3) non-coding sequence of DNA
Mature transcript
(1.3) RNA transcript that has been spliced and processed ready for translation
Messenger RNA (mRNA)
(1.3) carries a copy of the DNA code from nucleus to ribosome
Peptide bond
(1.3) strong chemical link between amino acids in the primary structure of a polypeptide
Phenotype
(1.3) outward appearance of an organism
Polypeptide
(1.3) short strand of amino acids
Primary transcript
(1.3) molecule made when DNA is transcribed
Ribose
(1.3) sugar that forms part of an RNA nucleotide
Ribosomal RNA (rRNA)
(1.3) type of RNA that makes up ribosomes
Ribosome
(1.3) site of protein synthesis; composed of rRNA and protein
RNA
(1.3) ribonucleic acid; several forms of single-stranded nucleic acid that are involved in protein synthesis
RNA polymerase
(1.3) enzyme which unwinds and unzips DNA and adds complementary nucleotides to form a primary transcript
RNA splicing
(1.3) joining of exons following the removal of introns from a primary transcript
Start codon
(1.3) first codon of a messenger RNA (mRNA) transcript translated by a ribosome
Stop codon
(1.3) codon within messenger RNA that signals a termination of translation into proteins
Transcription
(1.3) copying of DNA sequences to make a primary transcript
Transfer RNA (tRNA)
(1.3) transfers specific amino acids to the mRNA on the ribosomes
Translation
(1.3) production of a polypeptide at a ribosome using information encoded in mRNA
Uracil (U)
(1.3) RNA base not found in DNA; pairs with adenine in transcription and translation
Chromosome
(1.4) rod-lke structure that contains the genetic material of an organism encoded into DNA
Deletion (of genes)
(1.4) chromosome mutation in which a sequence of genes is lost from a chromosome
Deletion (of nucleotides)
(1.4) single gene mutation involving removal of a nucleotide from a sequence
Duplication
(1.4) chromosome mutation in which a section of chromosome is added from its homologous partner
Frame-shift mutation
(1.4) gene mutation in which all amino acids coded for after the mutation are affected
Insertion
(1.4) single gene mutation in which an additional nucleotide is placed into a sequence
Inversion
(1.4) chromosome mutation in which a set of genes rotates through 180°
Missense
(1.4) substitution mutation; a single nucleotide change results in a codon for a different amino acid
Mutation
(1.4) changes in the DNA that can result in absence of protein or synthesis of an altered protein
Nonsense
(1.4) substitution mutation in which a codon is changed to a stop codon, shortening the resulting protein
Protein
(1.4) large molecule made up of chains of amino acids linked by peptide bonds
Single gene mutations
(1.4) alteration of a DNA nucleotide sequence as a result of the substitution insertion or deletion of nucleotides
Splice-site mutation
(1.4) mutation at a point where coding and non-coding regions meet in a section of DNA
Substitution
(1.4) single gene mutation in which one nucleotide is replaced by another
Translocation
(1.4) chromosome mutation in which part of a chromosome becomes attached to another
Bioinformatics
(1.5) use of computers and statistics in analysis of sequence data
Genome
(1.5) total genetic material present in an organism
Genomic sequencing
(1.5) the process of determining the sequence of nucleotide bases for individual genes or entire genomes
Non-coding
(1.5) sequences of DNA that do not code for proteins, including those that are transcribed but not translated and sequences that are involved in gene regulation
Personalised medicine
(1.5) development in which treatment is based on an individuals genome
Pharmacogenetics
(1.5) the study of inherited differences that affect metabolic pathways which can influence individual therapeutic responses to, and side-effects of, drugs
Sequence data
(1.5) information concerning amino acid or nucleotide base sequences of a gene or
Activation energy
(1.6) input of energy required to start a chemical reaction
Active site
(1.6) region on an enzyme molecule where the substrate binds
Affinity
(1.6) attraction between the active site of an enzyme and its substrate
Anabolic reactions
(1.6) reactions which build up larger molecules from small molecules and which require energy
Catabolic reactions
(1.6) reactions which break down large molecules into smaller molecules and which release energy
Competitive inhibition
(1.6) slowing of reaction rate due to the presence of a substance resembling the substrate
End-product
(1.6) the final product of a series of reactions with enzymes in a metabolic pathway
Feedback inhibition
(1.6) enzyme inhibition caused by the presence of an end product of a metabolic pathway
Induced fit
(1.6) change to an enzyme’s active site brought about by its substrate
Metabolic pathway
(1.6) enzyme-catalysed sequence of chemical reactions in a cell
Metabolism
(1.6) the sum total of all the chemical reactions that take place in cells
Non-competitive inhibition
(1.6) enzyme inhibition by a substance that permanently alters the active site of the enzyme