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Question 1

What is the Acid Value?

Answer 1

This is the number of mg of KOH required to neutralise the free acids in 1g of the fat.

Question 2

What is indicated by a high acid value?

Answer 2

A high acid value indicates an inferior sample

Question 3

What is Saponification Value?

Answer 3

This is the number of KOH required to neutralise the free acids and the liberated acids after hydrolysis of the fat

Question 4

What is the Ester Value?

Answer 4

This is the number of mg of KOH required to neutralise the acids, which are liberated after hydrolysis

Question 5

How do you work out the saponification value?

Answer 5

Saponification value = Ester Value PLUS Acid Value

Question 6

How do you work out the Acid Value?

Answer 6

Acid Value = Saponification Value MINUS Ester Value

Question 7

How do you work out the Ester Value?

Answer 7

Ester Value = Saponification Value MINUS Acid Value

Question 8

What is the Iodine Value?

Answer 8

Is the number of parts of iodine mono chloride that is absorbed by 100 parts by weight of the fat.
This gives a measure of unsaturation in the fat

Question 9

What does O3FA have a role in prevention and management of?

Answer 9

• Inflammatory conditions such as rheumatiod arthritis, irritable bowel syndrome and psoriasis
• Diabetes Mellitus
• Mental conditions such as schizophrenia and depression

Question 10

What enzyme does simvastatin inhibit?

Answer 10

HMG-CoA reductase

Question 11

Which ring structure makes simvastatin a prodrug?

Answer 11

Lactone

Question 12

Simvastatin is a derivative from what naturally occuring lead compund?

Answer 12

Lovastatin

Question 13

What is the name of the biosynthetic pathway in which atrovastatin operates?

Answer 13

Mevalonate Pathway

Question 14

A dangerous but rare side effect of simvastatin?

Answer 14

Rhabdomyolysis

Question 15

When are simvastatin tablets normally taken?

Answer 15

In the evening

Question 16

Which substitution in the butanoate chain of lovastatin can bring about its conversion to simvastatin?

Answer 16

Substituting -H with -CH3

Question 17

A patient notices that iron oxide is present in simvastatin tablets. What is the purpose of this addition?

Answer 17

Colorant

Question 18

What is the lead compound if simvastatin?

Answer 18

Lovastatin

Question 19

Which type of particle takes cholesterol from the artery interior linings back to the liver?

Answer 19

HDL