All Lectures

Question 1

Oleaginous

Answer 1

Oily or Greasy

Question 2

Drug into skin depends on…

Answer 2

pressure applied, surface area covered, condition of skin, base used, occlusive dressing

Question 3

Paste

Answer 3

thick, stiff ointment that does not flow at body temperature, used as a protective coat, 20% solid

Question 4

Ointment

Answer 4

soften at body temp, spread easily, re-hydrate skin,

Question 5

Cream

Answer 5

applied to a soft, cosmetically acceptable area, active ingredient is suspended or dissolved, have a drying effect

Question 6

Epidermic
Endodermic
Diadermic

Answer 6

Little skin penetration, OIl
to dermis, absorpt. bases
though skin, water soluble emulsion

Question 7

Absorptive Bases
Oleaginous
Water soluble

Answer 7

Aquaphor
White Pet.
Polyethylene Glycol ung

Question 8

Levigation

Answer 8

for incorporating insoluble powders, example: wet powder and then add to white pet.

Question 9

Levigating agents

Answer 9

Glycol’s, Oils (mineral)

Question 10

Stiffening Agents

Answer 10

waxes and hard fats

Question 11

Water soluble bases

Answer 11

PEG 3350

Question 12

Modified release products provide…

Answer 12

1) Delayed Release

2) Extended Release

Question 13

Extended Release

Answer 13

release at a predetermined rate, duration and location to achieve optimum blood levels, constant level of drug, less side effects

Question 14

Delayed Release

Answer 14

designed to pass through the stomach unaltered, release med. in intestinal tract

Question 15

Repeat Action

Answer 15

2 doses, 1 for immediate release, 2 for delayed release

Question 16

Targeted Release

Answer 16

to a body region

Question 17

Extended Release Technology

Answer 17

phthalates for enteric or colonic drug delivery

Question 18

Coated beads, microspheres

Answer 18

drug is distributed into beads, small release fastest, big release slowest

Question 19

Multi-tablet System

Answer 19

each cap. contains mini-tablets for immediate and delayed release

Question 20

Slowly eroding or hydrophilic matrix system

Answer 20

slowly erodes in body fluids, progressively releasing drug for absorption

Question 21

Ion Exchange Resin

Answer 21

release is dependent on pH and electrolyte conc.

release better in acidic environment

Question 22

Osmotic Pump

Answer 22

Oros system, like a syringe in your stomach

Question 23

Drug release rate altered by…

Answer 23

surface area, thickness and composition of membrane, diameter of drug release orifice

Question 24

bioadhesion:
diffusion
electronic
wetting
fracture
adsorption

Answer 24

entanglement of polymer
attractive forces
getting wet
force 2 separate 2 surface
secondary chemical bonds

Question 25

Gelatin

Answer 25

used to adhere buccal route quickly

Question 26

Why ODT?

Answer 26

faster OA, improved compliance, better taste,

common and unique

Question 27

Lozenges

Answer 27

medial agent and flavor, softer texture b/c of high sugar content or PEG, hard lozenge from hard candy bases, for local treatment, easy to administer, can be gummy

Question 28

Hard Lozenges

Answer 28

are hydroscopic so take up moisture from environment, need to be protected from humidity,

Question 29

Suppositories

Answer 29

Suppositories

Question 30

Oil Soluble Bases

Answer 30

Cocoa butter, four forms, melt at 34-35C, 3-7 minutes to liquify

Question 31

Hydrogenated Veggie Oil Bases

Answer 31

Fattibase, 35-37C

Wecobee / Witepsol 3-7 minutes to liquify

Question 32

Water Soluble Bases

Answer 32

PEG suppositories, can be formulated to adapt to what chemist needs, 30-50 minutes to liquify

Question 33

Suppository Prep: Fusion Method

Answer 33

heat base, add ingredient then pour into mold and cool

Question 34

Prep of active drug

Answer 34

max excipeint is 30% of blank weight of suppository, 2ml size can hold 600mg of drug

Question 35

to maximize release of drug…

Answer 35

water soluble drugs should be placed in oil soluble bases and vise versa