All Drugs Flashcards
Edoxaban
Savaysa
MOA: Direct factor Xa inhib
Oral drug
Black box: Spinal or epidural hematoma, also do not stop this drug. WATCH CrCl and if its greater than 95 ml you can not use because you will clear it
Heparin
UFH (unfractionated heparin)
MOA: Potentiates activity of antithrombin (will bind to both Xa and IIa non-selective ) **must have antithrombin III
MUST WATCH FOR HIT: will lower platelet with will cause IgG to bind and increase chance of clot
Route: IV or Subcutaneous
Reversal done by Protamine
Ateplase
Activase
MOA: recombinat t-PA
Short half-life with moderately selective for fibrin
Best option
Tenectaplase
TNKase
MOA: recomb t-PA
Most selective for fibrin but has a very long half time
Long half life is the issue with this one so its not used as much
Aminocaproic Acid
Amicar
MOA: competitively inhibits activation of plasminogen to plasmin
Can be used to reverse t-PA drugs
Dipyridamole
Aggrenox (200 ER of dipry combo with aspirin 25mg)
Indication: Stroke / TIA (brain drug)
MOA: PDE-I; increase cAMP which decreased platelet activation
Tirofiban
Aggrastat
MOA: GP2b/3a antagonists
Dosing: IV bolus, CIVI follows
Cilostazol
Pletal
MOA: PDE-I, increased cAMP, which leads to decreased platelet activation
Used for PAD (leg pain associated with getting clots in your legs, need to get up and walk around to help it)
Fondaparinux
Arixtra (synthetic 5 sugar that binds selectively)
MOA: binds to antithrombin and is very selective for Xa
No HIT reported
Black box: Epidural or spinal hematomas
Given subcu
Abciximab
Reopro
MOA: GP2b/3a antagonist, blocking aggregation
Dosing: IV bolus, then give CIVI
Warfarin
Coumadin, tantovan
MOA: Vit K antagonist, and block Vkork (which stops the production of factor 1972 and protein C and S)
Can over come warfarin toxic by increases amounts of Vit K (Phytonadione)
Bivalirudin
Angiomax
MOA: directly block IIa (thrombin)
Dosing: IV then CIVI
Uses ACT test to change dose at bedside
Enoxaparin
Dalterparin
Lovenox (LMWH)
Fragmin
MOA: binds to Antithrombin III and makes it work better (binds to Xa much more than IIa)
Black box: epidural or spinal hematoma
Reversal is done by protamine
DaBIGatran
Pradaxa
MOA: blocks IIa
Given ORAL!
Black box: spinal / epidural hematoma and do not stop it
Ticlopidine
Ticlid
MOA: Permanently inhibits ADP receptor antagonist (P2Y12)
Prodrug; given with food
Indications : ACS and Thrombo stroke
Blackbox: Neutropenia/agranulocytosis, TPP
Aspirin
MOA: irreversible COX inhib (at low doses it only blocks COX-1
This keeps the platelets from coming together
Tranexamic Acid
MOA: lysine amino acid, which inhibits activation of plasminogen to plasmin
Can be used as a reversal for the fibrolytic drugs (recomb t-PA)
Clopidogrel
Plavix
MOA: Irreversibly binds P2Y12, ADP receptors antagonist
Prodrug; watch cyp 2c19
Blackbox warning: Watch people who have CYP2C19 ( watch use of PPIs)
Ticagrelor
Brilinta
MOA: REVERSIBLY binds P2Y12 (ADP antag)
ACTIVE DRUG
Used for: ACS (heart)
Black box: use with aspirin but must be low dose in bellow 100 mg
Rivaroxaban
Xarelto
MOA: Direct factor Xa inhibitor
Oral drug
Black box: Spinal or epidural hematoma
Prasugrel
Effient
MOA: Irreversibly binds P2Y12 (ADR antag)
PRO drug : watch 3A and 2B6 cyp
Only used for ACS (heart)
Black Box: can not be used over 75 and must weigh more than 60 kg
AnDEXAnet alfa (clue for what it is used for )
AndexXA
MOA: recominant factor Xa
Used to reverse effects of Apixaban (eliquis) and Rivaroxaban (Xarelto) ONLY!!!!!!
Idarucizumab
Praxbind
MOA: binds to daBIGatran and inactivates it so it doesn’t bind to thrombin
Argatroban
Argatroban
MOA: Blocks IIa
Indication for HIT positive pts
Dose: give IV, used aPTT test
