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Blood Clotting Drugs > All Drugs > Flashcards

All Drugs Flashcards

1
Q

Edoxaban

A

Savaysa

MOA: Direct factor Xa inhib

Oral drug

Black box: Spinal or epidural hematoma, also do not stop this drug. WATCH CrCl and if its greater than 95 ml you can not use because you will clear it

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2
Q

Heparin

A

UFH (unfractionated heparin)

MOA: Potentiates activity of antithrombin (will bind to both Xa and IIa non-selective ) **must have antithrombin III

MUST WATCH FOR HIT: will lower platelet with will cause IgG to bind and increase chance of clot

Route: IV or Subcutaneous

Reversal done by Protamine

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3
Q

Ateplase

A

Activase

MOA: recombinat t-PA

Short half-life with moderately selective for fibrin

Best option

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4
Q

Tenectaplase

A

TNKase

MOA: recomb t-PA

Most selective for fibrin but has a very long half time

Long half life is the issue with this one so its not used as much

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5
Q

Aminocaproic Acid

A

Amicar

MOA: competitively inhibits activation of plasminogen to plasmin

Can be used to reverse t-PA drugs

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6
Q

Dipyridamole

A

Aggrenox (200 ER of dipry combo with aspirin 25mg)

Indication: Stroke / TIA (brain drug)

MOA: PDE-I; increase cAMP which decreased platelet activation

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7
Q

Tirofiban

A

Aggrastat

MOA: GP2b/3a antagonists

Dosing: IV bolus, CIVI follows

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8
Q

Cilostazol

A

Pletal

MOA: PDE-I, increased cAMP, which leads to decreased platelet activation

Used for PAD (leg pain associated with getting clots in your legs, need to get up and walk around to help it)

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9
Q

Fondaparinux

A

Arixtra (synthetic 5 sugar that binds selectively)

MOA: binds to antithrombin and is very selective for Xa

No HIT reported

Black box: Epidural or spinal hematomas

Given subcu

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10
Q

Abciximab

A

Reopro

MOA: GP2b/3a antagonist, blocking aggregation

Dosing: IV bolus, then give CIVI

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11
Q

Warfarin

A

Coumadin, tantovan

MOA: Vit K antagonist, and block Vkork (which stops the production of factor 1972 and protein C and S)

Can over come warfarin toxic by increases amounts of Vit K (Phytonadione)

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12
Q

Bivalirudin

A

Angiomax

MOA: directly block IIa (thrombin)

Dosing: IV then CIVI

Uses ACT test to change dose at bedside

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13
Q

Enoxaparin

Dalterparin

A

Lovenox (LMWH)
Fragmin

MOA: binds to Antithrombin III and makes it work better (binds to Xa much more than IIa)

Black box: epidural or spinal hematoma

Reversal is done by protamine

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14
Q

DaBIGatran

A

Pradaxa

MOA: blocks IIa

Given ORAL!

Black box: spinal / epidural hematoma and do not stop it

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15
Q

Ticlopidine

A

Ticlid

MOA: Permanently inhibits ADP receptor antagonist (P2Y12)

Prodrug; given with food

Indications : ACS and Thrombo stroke

Blackbox: Neutropenia/agranulocytosis, TPP

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16
Q

Aspirin

A

MOA: irreversible COX inhib (at low doses it only blocks COX-1

This keeps the platelets from coming together

17
Q

Tranexamic Acid

A

MOA: lysine amino acid, which inhibits activation of plasminogen to plasmin

Can be used as a reversal for the fibrolytic drugs (recomb t-PA)

18
Q

Clopidogrel

A

Plavix

MOA: Irreversibly binds P2Y12, ADP receptors antagonist

Prodrug; watch cyp 2c19

Blackbox warning: Watch people who have CYP2C19 ( watch use of PPIs)

19
Q

Ticagrelor

A

Brilinta

MOA: REVERSIBLY binds P2Y12 (ADP antag)

ACTIVE DRUG

Used for: ACS (heart)

Black box: use with aspirin but must be low dose in bellow 100 mg

20
Q

Rivaroxaban

A

Xarelto

MOA: Direct factor Xa inhibitor

Oral drug

Black box: Spinal or epidural hematoma

21
Q

Prasugrel

A

Effient

MOA: Irreversibly binds P2Y12 (ADR antag)

PRO drug : watch 3A and 2B6 cyp

Only used for ACS (heart)

Black Box: can not be used over 75 and must weigh more than 60 kg

22
Q

AnDEXAnet alfa (clue for what it is used for )

A

AndexXA

MOA: recominant factor Xa

Used to reverse effects of Apixaban (eliquis) and Rivaroxaban (Xarelto) ONLY!!!!!!

23
Q

Idarucizumab

A

Praxbind

MOA: binds to daBIGatran and inactivates it so it doesn’t bind to thrombin

24
Q

Argatroban

A

Argatroban

MOA: Blocks IIa

Indication for HIT positive pts

Dose: give IV, used aPTT test

25
Q

Apixaban

A

Eliquis

MOA: Direct factor Xa inhib

Oral drug

Black box: Spinal or epidural hematoma, also don’t stop

26
Q

AndeXa

A

This will reverse the effects of Xa inhibitors

Only used for xeralto and eliquis at this time

27
Q

Eptifibatide

A

Integrilin

MOA: GP2b/3a antagonist

Dosing: IV bolus followed by CIVI

28
Q

Reteplase

A

Retevase

MOA: Mutation of t-PA

Less selective for fibrin with short half-life

Not used as much due to the low selectivity for fibrin

Blood Clotting Drugs (1 decks)

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