all

Question 1

Medullary thyroid cancer is associated with what gene mutation?

Answer 1

RET (MEN 2A, 2B)

Question 2

Papillary thyroid cancer, melanoma, and non-Hodgkin lymphoma is associated with what gene mutation?

Answer 2

BRAF

Question 3

Follicular lymphoma and adenoma is associated with what genetic mutation?

Answer 3

PPAR-y/PAX8 fusion

Question 4

Osmotic myelinolysis is a side effect of what?

Answer 4

Raising sodium too high. This causes demylination of neurons int he brain

Question 5

Vitamin E (tocopherol) deficiency manifests with what symptoms

Answer 5

Hemolytic anemia - low haptoglobin
Posterior column - proprioception
Spinocerebellar tract - Romberg test

Question 6

Vitamin B6 deficiency manifests as what kind of anemia?

Answer 6

Sideroblastic microcytic anemia

Question 7

Method of action of tetanospasmin

Answer 7

Blocks the release of glycine and GABA from inhibitory cells

Question 8

Rheumatoid factors target which part of IgG

Answer 8

Fc region of IgG

Question 9

Rheumatoid arthritis is associated with which HLA?

Answer 9

DR4, DR1

Question 10

Patient went to Chile and now having fever, headaches, facial lympadenopathy, and periorbital swelling

Answer 10

Chagas disease

Question 11

The diencephalon gives rise to what part of the brain

Answer 11

Third ventricle

Question 12

Method of action of Entacapone

Answer 12

Peripherally inhibits COMT which reduces methylation of levodopa to dopamine

Question 13

Method of action of carbidopa

Answer 13

Decreases the conversion of levodopa to dopamine in the periphery

Question 14

Method of action of Ropinirole

Answer 14

Dopamine agonist. Used in young parkinsons patients

Question 15

MEthod of action of amantadine

Answer 15

NMDA antagonist, increasing release of dopamine and decreasing reuptake

Question 16

MAO-B inhibitors method of action

Answer 16

Decrease dopamine degredation in the brain