ALL

Question 1

Types of All (acute lymphoblastic leukemia)

Answer 1

B-ALL
T-ALL

Question 2

What markers are known for B-ALL?

Answer 2

CD10, CD19 and CD 20

Question 3

Which translocations occur in B-ALL?

Answer 3

Bi translocations
Chromosome 9-22 (adults, more aggressive) /Philadelphia chromosome
Chromosome 12-21 (children, less aggressive)

Question 4

What markers are known for T-ALL?

Answer 4

CD2-CD8

Question 5

what’s the normal percentage of myeloblasts in the bone marrow? And what are the abnormal percentages with their concordance to diseases?

Answer 5

Normal ratio is 1-2% in the bone marrow. Once they arise to 10% and more, they present a case of MDS. The MDS is a precursor for CML. Once the ratio reaches 20% or more, then it’s a CML.

Question 6

Where do B and T cells mature?

Answer 6

B cells mature in the Bone marrow, whereas T cells mature in the Thymus.

Question 7

Types of lymphomas?

Answer 7

-Premature B Cell lymphoma
-peripheral B cell lymphoma
-premature T Cell lymphoma
Peripheral T cell and nK Cell lymphoma
-Hodgkin lymphoma

Question 8

Auer rods are found in?

Answer 8

B-ALL

Question 9

Rituximab is for which Marker?

Answer 9

CD20