Aligning Multiple Sequences Flashcards
1
Q
Why is multiple alignment necessary?
A
Orthologues from different species
Paralogues from gene duplications
2
Q
Why are there more than one protein kinases?
A
Differ in substrates, associated domains or tissues of expression
Some lack a functional catalytic site
3
Q
What are multiple alignments used for?
A
Function prediction
Phylogeny
Structure prediction
Homology detection
4
Q
What is time in s proportional to?
A
L^N
(N sequences of length L)
5
Q
What are 4 characteristics of progressive multiple sequence alignment?
A
Not guaranteed to get computationally optimal solution
allows job to be completed in time
may recover true alignment of homologous residues as occurred in evolution
can make mistakes, especially among distant sequences
6
Q
A
