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rheumatology > algorithms and biomarkers > Flashcards

algorithms and biomarkers Flashcards

1
Q

what to do with an abnormal LFT/ ALT of >100 on a DMARD

A

stop therapy for 2 weeks and re-check

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2
Q

what if the ALT is still over 100 after 2 weeks

A

contact rheumatology service

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3
Q

what if the ALT is less than 100 after 2 weeks

A

recommence DMARD at lower dose

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4
Q

what to do with an abnormal LFT ALT of 50-100

A

continue treatment and recheck to see if ALT is stable- then call rheum service if not

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5
Q

what are abnormal FBC on a dmard requiring stop for 2 weeks

A

platelets <150
WCC <4
neutrophils<2

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6
Q

what values on an FBC means DMARDS should be stopped completely and rheum contacted

A

platelets <100
wcc: <2
neutrophils <1

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7
Q

how much should methotrexate be reduced

A

5mg week

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8
Q

sulfasalzine reduced

A

500mg/day

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9
Q

azathioprine reduced

A

50mg/day

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10
Q

leflunomide reduced

A

10mg/day

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11
Q

mycophenylate reduce

A

500mg/day

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12
Q

rheumatoid arthritis typical biomarkers

A 
rheumatoid factor +
ESR ^
CRP^
ANA +
ACPA+
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13
Q

most specific biomarker for rheumatoid

A

ACPA

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14
Q

typical biomarkers for sjorgren

A 
RF +
ESR^
ANA+
anti ENA:
- ANTI RO/LA +
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15
Q

typical biomarkers for SLE

A 
ESR^
normal CRP
\+ANA
ANAEMIA
Ds-DNA +
low c3/c4 
neutopaenia
lymphopaenia
anti-ENA
-anti-sm
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16
Q

systemic sclerosis typical biomarkers

A

ESR ^
ANA +
IgG
antibody to topisomerase

17
Q

typical biomarkers for gout

A

esr^
crp^
neutrophilia
urate crystals

18
Q

typical biomarkers for pseudo-gout

A

esr^
crp^
CPPD crystals
neutrophilia

19
Q

typical biomarkers for septic arthritis

A

esr^
crp^
leucocytes
neutrophilia

20
Q

typical biomarkers for ank spondylitis

A

RF, ANA,ACPA -
esr^
crp^
HLA-B27 +

21
Q

reactive arthritis typical biomarkers

A

rf, ana, acpa -
esr^
crp^
leucocytes

22
Q

psoriatic arthritis biomarkers

A

rf, ana, acpa -
esr ^
crp^

23
Q

giant cell arteritis biomarkers

A

esr or crp^

anaemia

24
Q

what does anti-ccp stand for or acpa

A

anti cyclic citrullinated pepetide

25
Q

what does ds dna stand for

A

double stranded dna

26
Q

what does anti-ENA stand for

A

anti extractable nuclear antigens

27
Q

what does anca stand for

A

anti-neutrophil cytoplasmic antibodies

28
Q

what does ana stand for

A

anti-nuclear antibodies

29
Q

mixed connective tissue disease biomarker

A

anti ENA

-anti RNP

30
Q

vasculitis biomarker

A

ANCA

31
Q

reactive arthritis cause

A 
food poisoning
-salmonella
-shigella
-campylobacter
-Yersinia
STI
-chlamydia
32
Q

septic arthritis main causes

A
  • staph. aureus

- disseminated gonococcal infection

rheumatology (9 decks)

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