Alcohol & Liver Drugs Flashcards
1
Q
Naltrexone
A
Opioid receptor antagonist
Blocks alcohol-induced release of dopamine from nucleus accumbens
-> Diminishes pleasurable effects and cravings for alcohol
Most clinically successful when used with Sinclair method
2
Q
Nalmedene
A
Alpha and miu opioid receptor antagonist
Less hepatotoxic than naltrexone
3
Q
Tiapride
A
D2 dopamine receptor antagonist
Ease withdrawal symptoms for treatment of acute & chronic alcoholism
4
Q
Acamprosate
A
GABA receptor agonist
Normalise glutamanergic-mediated reaction to alcohol withdrawal
-> Improve abstinence
5
Q
Disulfiram
A
Irreversible inhibitor of ALDH
Makes drinking alcohol unpleasant
Adherence is important
