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2nd Yr > ALCOHOL CLASP > Flashcards

ALCOHOL CLASP Flashcards

1
Q

In hepatocytes, alcohol is associated with an accumulation of?

A

Lipids

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2
Q

Treatments intended to manage ascites in cirrhosis aims to reduce

A

sodium levels

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3
Q

Acute pancreatitis is associated with

A

steroid use

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4
Q

In the heart, Chronic alcoholism is associated with?

A

dilated cardiomyopathy

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5
Q

Fibrosis.cirrhosis of the liver is mediated by which type of cell?

A

Hepatic stellate cells/interstitial cells of Ito

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6
Q

Which clinical sign can be associated with alcohol?

A

Caput medusa

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7
Q

Persistent vomiting may result in what type of ABG picture?

A

metabolic alkalosis

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8
Q

Antabuse - a drug used to treat alcoholism work by inhibiting

A

aldehyde dehydrogenase

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9
Q

A patient with haematemesis may suffer from

A

Hypobolaemic shock

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10
Q

The respiratory center of the brain lies within the

A

brainstem

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11
Q

The recommended number of units of alcohol for a man in one week is

A

14 units

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12
Q

The term “inotrope” refers to

A

cardiac contractility

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13
Q

Alcohol is initially metabolised by

A

alcohol dehydrogenase

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14
Q

In a restaurant today a standard glass of wine (175mls) is likely to contain approximately

A

2 units of alcohol

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15
Q

The recommended number of units of alcohol for a woman in one week is

A

14 units

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16
Q

A patient with LFTs showing a normal GGT, AST and ALT with high Alk Phos is most likely to have

A

bone disease

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17
Q

Persistent vomiting causing a gastric tear is known as a

A

Boerrhave Syndrome

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18
Q

Alcohol confers the strongest risk for

A

hepatocellular carcinoma

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19
Q

Which nerve supplies the heart?

A

Vagus

20
Q

Dupuytren’s contracture is caused by

A

scarring of the palmar fascia

21
Q

What does ALT stand for?

A

Alanine transaminase

22
Q

What does AST stand for?

A

Aspartate aminotransferase

23
Q

Where is ALP concentrated?

A

liver, bile duct and bone tissue

24
Q

Where is ALT concentrated?

A

Hepatocytes

25
Q

A raised ALT indicates?

A

hepatocellular injury

26
Q

ALP is often raised in response to?

A

Increased synthesis in response to liver pathology - commonly cholestasis.

27
Q

A greater than 10-fold increase in ALT and a less than 3-fold increase in ALP suggests a predominantly

A

hepatocellular injury

28
Q

A less than 10-fold increase in ALT and a more than 3-fold increase in ALP suggests

A

cholestasis

29
Q

Which LFT is raised in response to alcohol?

A

GGT

30
Q

GGT is raised in response to?

A

biliary epithelial damage
bile flow obstruction
alcohol

31
Q

ALT > AST is seen in

A

chronic liver disease

32
Q

AST > ALT

A

cirrhosis and acute alcoholic hepatitis

33
Q

Which clotting factor is NOT made in the liver?

A

VIII

34
Q

In general, females become intoxicated more rapidly than males because

A

they tend to have less alcohol dehydrogenase

35
Q

Aspiration pneumonia typically occurs in the

A

superior segment of the right lower lobe

36
Q

Embryologically the liver is derived from the

A

Foregut

37
Q

Jaundice as a result of alcoholic hepatitis is caused by an accumulation of

A

conjugated bilirubin

38
Q

The liver is divided into

A

8 segments

39
Q

After use of muscle glycogen the liver can produce “new glucose” through

A

gluconeogenesis

40
Q

Alkaline phosphatase is NOT concentrated in the

A

lung

41
Q

Portal hypertension is most associated with

A

splenomegaly

42
Q

Alcohol is known to be associated with an increase in?

A

precipitation of uric acid

43
Q

Alcohol is initially metabolised by

A

alcohol dehydrogenase

44
Q

Microscopically, hepatocytes are bordered by

A

the space of Disse

45
Q

Which of these microscopic features is NOT present within a portal tract?

A

Hepatocyte

46
Q

Whichfeatures are present within a portal tract?

A

branch of hepatic portal vein
branch of hepatic artery
lymphatics
bile ductule

2nd Yr (3 decks)

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