ALCOHOL CLASP

Question 1

In hepatocytes, alcohol is associated with an accumulation of?

Answer 1

Lipids

Question 2

Treatments intended to manage ascites in cirrhosis aims to reduce

Answer 2

sodium levels

Question 3

Acute pancreatitis is associated with

Answer 3

steroid use

Question 4

In the heart, Chronic alcoholism is associated with?

Answer 4

dilated cardiomyopathy

Question 5

Fibrosis.cirrhosis of the liver is mediated by which type of cell?

Answer 5

Hepatic stellate cells/interstitial cells of Ito

Question 6

Which clinical sign can be associated with alcohol?

Answer 6

Caput medusa

Question 7

Persistent vomiting may result in what type of ABG picture?

Answer 7

metabolic alkalosis

Question 8

Antabuse - a drug used to treat alcoholism work by inhibiting

Answer 8

aldehyde dehydrogenase

Question 9

A patient with haematemesis may suffer from

Answer 9

Hypobolaemic shock

Question 10

The respiratory center of the brain lies within the

Answer 10

brainstem

Question 11

The recommended number of units of alcohol for a man in one week is

Answer 11

14 units

Question 12

The term “inotrope” refers to

Answer 12

cardiac contractility

Question 13

Alcohol is initially metabolised by

Answer 13

alcohol dehydrogenase

Question 14

In a restaurant today a standard glass of wine (175mls) is likely to contain approximately

Answer 14

2 units of alcohol

Question 15

The recommended number of units of alcohol for a woman in one week is

Answer 15

14 units

Question 16

A patient with LFTs showing a normal GGT, AST and ALT with high Alk Phos is most likely to have

Answer 16

bone disease

Question 17

Persistent vomiting causing a gastric tear is known as a

Answer 17

Boerrhave Syndrome

Question 18

Alcohol confers the strongest risk for

Answer 18

hepatocellular carcinoma

Question 19

Which nerve supplies the heart?

Answer 19

Vagus

Question 20

Dupuytren’s contracture is caused by

Answer 20

scarring of the palmar fascia

Question 21

What does ALT stand for?

Answer 21

Alanine transaminase

Question 22

What does AST stand for?

Answer 22

Aspartate aminotransferase

Question 23

Where is ALP concentrated?

Answer 23

liver, bile duct and bone tissue

Question 24

Where is ALT concentrated?

Answer 24

Hepatocytes

Question 25

A raised ALT indicates?

Answer 25

hepatocellular injury

Question 26

ALP is often raised in response to?

Answer 26

Increased synthesis in response to liver pathology - commonly cholestasis.

Question 27

A greater than 10-fold increase in ALT and a less than 3-fold increase in ALP suggests a predominantly

Answer 27

hepatocellular injury

Question 28

A less than 10-fold increase in ALT and a more than 3-fold increase in ALP suggests

Answer 28

cholestasis

Question 29

Which LFT is raised in response to alcohol?

Answer 29

GGT

Question 30

GGT is raised in response to?

Answer 30

biliary epithelial damage bile flow obstruction alcohol

Question 31

ALT > AST is seen in

Answer 31

chronic liver disease

Question 32

AST > ALT

Answer 32

cirrhosis and acute alcoholic hepatitis

Question 33

Which clotting factor is NOT made in the liver?

Answer 33

VIII

Question 34

In general, females become intoxicated more rapidly than males because

Answer 34

they tend to have less alcohol dehydrogenase

Question 35

Aspiration pneumonia typically occurs in the

Answer 35

superior segment of the right lower lobe

Question 36

Embryologically the liver is derived from the

Answer 36

Foregut

Question 37

Jaundice as a result of alcoholic hepatitis is caused by an accumulation of

Answer 37

conjugated bilirubin

Question 38

The liver is divided into

Answer 38

8 segments

Question 39

After use of muscle glycogen the liver can produce "new glucose" through

Answer 39

gluconeogenesis

Question 40

Alkaline phosphatase is NOT concentrated in the

Answer 40

lung

Question 41

Portal hypertension is most associated with

Answer 41

splenomegaly

Question 42

Alcohol is known to be associated with an increase in?

Answer 42

precipitation of uric acid

Question 43

Alcohol is initially metabolised by

Answer 43

alcohol dehydrogenase

Question 44

Microscopically, hepatocytes are bordered by

Answer 44

the space of Disse

Question 45

Which of these microscopic features is NOT present within a portal tract?

Answer 45

Hepatocyte

Question 46

Whichfeatures are present within a portal tract?

Answer 46

branch of hepatic portal vein branch of hepatic artery lymphatics bile ductule