Alcohol Flashcards

1
Q

What are the affects of alcohol in lower doses?

A
  • Euphoria
  • Reduced anxiety
  • Relation
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2
Q

What are the affects of alcohol in higher doses?

A
  • Intoxication (the pathological state produced by a drug, serum, alcohol, or any toxic substance; poisoning)
  • Impaired attention and judgement
  • Unsteadiness
  • Flushing
  • Nystagmus
  • Mood instability
  • Disinhibition
  • Slurring
  • Stupor
  • Unconsciousness
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3
Q

What is the harful use of alcohol classified as?

A

Harmful use: pattern of use causing damage to physical or mental health. Use >1 month or repeatedly over 12 months

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4
Q

How is alcohol dependence diagnosed?

A

○ Dependence: 3 or more of the following for >1 month or repeatedly over 12 months

  • Cravings/ compulsions to take
  • Difficulty controlling use
  • Primacy (where you rank alcohol in your priorities)
  • Increased tolerance
  • Physiological withdrawal on reduction/ cessation
  • Persistence despite harmful consequences
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5
Q

What is the definition of a withdrawal state?

A

Withdrawal state: Group of symptoms of variable clustering and severity on complete/ relative withdrawal of a psychoactive substance, after persistent use of that substance

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6
Q

What are the symptoms of the alcohol withdrawal state?

A
○ Tremor
○ Weakness
○ Nausea
○ Vomiting
○ Anxiety 
○ Seizures
○ Confusion
○ Agitation 
○ Death
○ Delirium Tremens
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7
Q

What neurological problems can alcohol cause?

A
□ Brain damage
□ Loss of memory
□ Hallucinations
□ Fits
□ Dementia 
□ Tingling nerves
□ Numbness
□ Trembling hands
□ Confusional state 
□ Korsakoff's/ Wernicke's
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8
Q

What is Korsakoff’s/ Wernicke’s caused by?

A

® Caused by thiamine deficiency
◊ Poor intake and poor absorption
◊ Poor hepatic function
◊ Increased requirement for alcohol metabolism

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9
Q

What are the symptoms of Wenicke’s encephalopathy?

A

◊ Confusion
◊ Ataxia
◊ Ophthalmoplegia
◊ Nystagmus

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10
Q

What are the symptoms of Korsakoff’s psychosis?

A
◊ Prominent impairment of recent and remote memory
◊ Preservation of immediate recall
◊ No general cognitive impairment
◊ Retrograde and antegrade memory
◊ Impaired learning and disorientation
◊ May exhibit nystagmus and ataxia
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11
Q

What pulmonary problems can alcohol cause?

A

□ Risk of chest infection

□ Infection

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12
Q

What cardiovascular problems does alcohol cause?

A

□ Enlarges heart
□ High blood pressure
□ Irregular

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13
Q

What GI problems does alcohol cause?

A
□ Swollen liver
□ Hepatitis 
□ Cirrhosis
□ Pancreatitis
□ Ulcers
□ Gastritis
□ Vomiting blood
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14
Q

What reproduction problems does alcohol cause?

A

□ Risk of STIs and HIV/ AIDs
□ Impotence in men
□ Infertility in women

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15
Q

What physical problems (other than in neuro, cadio, pulmonary, GI and repro) does alcohol cause?

A
- Endocrine
□ Poor control of diabetes
- MSK
□ Loss of muscle
- Accidental injury
- Violence
- Cancer
□ Mouth
□ Oesophagus
□ Liver
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16
Q

What mental health problems does alcohol cause?

A
  • Anxiety
  • Depression
  • Sleep disruption
    □ Doesn’t promote REM sleep which helps with long term and short term memory
  • Morbid jealousy
  • Alcoholic hallucinosis
    □ Has a similar nature as delirium Tremens but not as severe and not life threatening
  • Deliberate self-injury
  • Suicidal thoughts/ acts
17
Q

What problems outside of physical and mental health problems does alcohol cause?

A
○ Relationships		
- Aggression
□ Verbal
□ Physical
- Marital difficulties 
□ Morbid jealousy
- Poor parenting/ neglect +/- loss of parenting rights
- Loss of friendships and social support
○ Employment, financial
○ Legal
18
Q

What are the staging tools for alcohol?

A

○ CAGE
- Have you tried to Cut down?
- Have you ever felt Annoyed by people criticising your drinking?
- Have you ever felt Guilty about drinking?
- Have you felt the need to have an Eye-opener?
○ AUDIT (alcohol Use Disorders Identification Test)
○ FAST (4 questions)
○ PAT (Paddington Alcohol Test; used in A and E)

19
Q

How is alcoholism managed?

A

○ Practical advice, education, harm reduction
○ Holistic/ bio-psycho-social approach
- Support for the patient and family
- Psychological help (e.g. CBT, group therapy)
- Social work input (benefits, housing, child protection)
- Skill training
- Community support (e.g. AA, ADA)
- Inpatient or residential treatment
- Medication

20
Q

What medication is given in the managment of alcoholism?

A
□ Prevention of Wernicke-Korsakoff syndrome
® Thiamine
□ Management of alcohol withdrawal
® Benzodiazepines, commonly chlordiazepoxide 
□ Aversion/ deterrent medication
® Disulfiram (Antabuse)
□ Anti-craving medication
® Acamprosate
® Naltrexone
® Nalmefene
® (Baclofen)
21
Q

How is fatty liver diagnosed?

A

US, CT, MRI

22
Q

What is fatty liver?

A

○ >60g of alcohol daily
○ Liver cells replaced by fatty acids and glycerol
○ Benign and reversable
○ Can progress to acute liver cirrhosis

23
Q

Talk about acute alcoholic hepatitis

A

○ >8 units of alcohol a day
○ Severe inflammation of the liver
○ No treatment at the moment

24
Q

Talk about varices

A

○ Secondary to cirrhosis and PHT (pulmonary hypertension)
○ Oesophagus, stomach, abdominal wall and rectum
○ >size >pressure >risk of bleeding
○ Every bleed is associated with 30% mortality

25
Q

Talk about hepatocellular cancer

A

○ 1/3 is caused by alcohol
○ Median survival 6-20 months
○ Leading cause of mortality world wide
○ Treatment: TACE, RFA, MWA, surgery, transplantation, chemotherapy

26
Q

Talk about pancreatic cancer

A

○ Ongoing pancreatitis is a risk factor for this
○ Poor prognosis
○ 5 year survival is 5%
○ Palliative therapy

27
Q

Talk about oesophageal cancer

A

○ >30g/ day alcohol use >risk of SCC
○ Dysphagia
○ 5 year survival rate about 20%

28
Q

What does a child with foetal alcohol syndrome look like?

A
○ Small head flat face
○ Epicanthal folds
○ Smooth philtrum
○ Thin upper lip
○ Small eye openings
29
Q

What is Delirium Tremens?

A
  • Profound confusion, tremor, agitation, hallucinations, delusions, sleeplessness, autonomic over-activity
  • Mortality in DTs= 5%
  • Death: cardiovascular collapse, infection, hyperthermia, seizures or self injury
  • Usually 48-72 hours after alcohol stopped