Alcohol Flashcards

1
Q

What percentage of the world population has consumed alcohol?

A
  • Women: 33%
  • Men: 50%
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2
Q

Is alcohol different than drugs?

A
  • Alcohol and drugs are considered different, but alcohol is a drug
  • There is even a different institutions at the NIH
    • NIAAA- National Institute on Alcohol Abuse and Alcoholism
    • NIDA- National Institute on Drug Abuse
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3
Q

How was alcohol first created?

A
  • It was likely first “discovered” by accident, as all that is requird is organic material with sugar content left alone in a warm container
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4
Q

Why were the conditions for accidental creation to alcohol appropriate?

A
  • all that is requried is organic material with sugar content left alone in a warm container
    • When this setup occurs, microscopic yeast cells in the air contact the material, consume it, and release alcohol in the process
    • This basic process can result in wines with alcoholic content between 12 and 15%
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5
Q

How are alcoholic drinks created?

A
  • Ethanol is produced by fermentation of sugars by yeasts.
    • Yeast transforms 1 molecule sugar into 2 molecules alcohol and 2 CO2
    • CO2 bubbles out, alcohol remains
  • Sugars may come from grapes (wine), rice (sake), or grains (beer)
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6
Q

What happens at a 15% ethanol level?

A

When the ethanol level is about 15%, the yeasts die. Thus, a separate process is needed to raise alcoholic content.

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7
Q

How can the ethanol level be increased beyond 15%

A

Distillation can then increase the alcohol concentration to produce whiskey, brandy, rum, etc.

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8
Q

How is beer made? How is the process any different?

A
  • Separately, the creation of beer is a more complex process than that of wine, thorugh the process of brewing
    • Barley is soaked in water (producing enzyme that can break starches into sugar), dried into barley malt, and crushed into a powder
    • Barley malt is combined with other elements (water, corn, rice) to make mash
    • Water activates enzymes to transform starches into sugars, and the addition of yeast begins the fermentation process.
    • Blossoms of hop plant added for flavor and aroma
    • Generally results in alcohlic content around 4.5%
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9
Q

How is liquor made?

A
  • Alcohol has a lower boiling point than water
  • Boil fermented alcohol
    • The pure alcohol transformed into vapor and collected, creating distilled spirits with higher alcohol content
    • Can take the 40-50% alcohol result and do it again, up to 90% alcohol
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10
Q

What is “proof”?

A
  • Alcoholic content at these levels is often in the form of “proof”, which is twice the percentage of the alcoholic content
    • 100 proof= 50% alcoholic content
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11
Q

What was the first alcoholic drink recored? what about other drinks? first distillation?

A
  • Mead, fermented from honey, was likely the first alcoholic drink, dating back to 8000 B.C.
  • Wine-stained pottery has been found in Iran dating back to 5400 B.C.
  • Beer came later, with frist official brewery by Egyptian around 3700 B.C.
    • Process was closer to baking, resultin in a beer that had low water content and was closer to bread
  • First ditillation was at medical school in Salerno, Itally in middle ages
    • Known as aqua vitae “water of life” for medical applications, other realized its abuse potential
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12
Q

What is the history of gin?

A
  • Dutch perfected the distillation flavoring with juniper berries, creating gin
    • Because it was cheap to produce and high in alcohol content, it began to be consumed widely, especially among the poor
      • self-medication?
    • Rose to crisis levels in England
    • In 1750 22 times the level of 1685
      • High infant mortality (1 of 4 or 5 babies surviving to age of 5)
      • in some areas of the city 1 of 5 homes was a gin shop
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13
Q

Alcohol in America:

Who brought it?

Why was it important?

A
  • Pilgrims brought alcohol in the Mayflower
  • Taverns became the place to discuss politics, business and mail delivery
  • In 1830 there was an average 5 drinks/day
  • Whiskey breaks, like coffee breaks, 11AM and 4PM
  • Harvard students had their own brewery
  • George Washigton had the biggest distillery of his time
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14
Q

When did the temperance movement began? consequences?

A
  • Around 1830-> Temperance movement
    • Started with moderation, only against distilled
    • Resulted in reduction per capita from 7gallons/year -> 2 gallons/year
  • In 1917- 1920 activity results 18th amendment of the Constitution prohibiting
    • “manufacture, sale, transportation, and importation” of liquor
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15
Q

Prohibiton:

A
  • In 1920, the 18th Amendment to the Constitution prohibited the “manufacture, sale, transportation, and importation” of liquor
  • There were many unintended consequences of prohibition:
    • Illegal manufacture of alcohol increased, sometimes in toxic forms.
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16
Q

What were the consequences of Prohibition?

A
  • Consumed of distilled spirits increased
  • Medicinal tonics contained up to 75% alcohol
  • Drinking in speakeasies became a fad
  • Increased activity of organized crime mobs that were involved in the sale and distribution of alcohol
17
Q

What about alcohol in the US today?

A
  • Today the use of alcohol is restricted by age and regulated by an increased tax
  • Americans drink about 1.5 drinks a day
  • A portion of the population is responsible for the majority of consumption
    • 30% of the Americans drink 80% of the total
    • 10% account for 50% of the total
18
Q

Alcohol and Nutrition:

A
  • Although alcohol is high in calories, it provides no proteins, vitamins, or minerals necessary for normal diet
  • Individuals who chronically consume large quantities of alcohol in lieu of food often suffer form inadequate nutrition, leading to health problems and brain damage.
19
Q

What are the different types of alcohol?

A
  • Ethyl alcohol (ethanol) is the form used in bevarages
  • Methyl alcohol (wood alcohol) is highly toxic- the liver metabolites include formic acid and formaldehyde; causes blindness, coma, and death.
20
Q

How is alcohol absorbed?

A
  • Ethanol is easily absorbed from the GI tract and diffuses throughout the body, readily entering most tissues, including the brain.
  • Many factors inflluence blood levels of ehtanol; thus behavioral effects are described on the basis of blood alcohol concentration (BAC) rather than the amount ingested
21
Q

What is BAC?

A
  • BAC is the blood alcohol concentration
  • BAC is dependent on the amount of alcohol consumed
  • A 12-oz can of beer, one 5-oz glass of wine, a cocktail with 1.5 oz of spirits, or a 12-oz wine cooler, will each raise your BAC by the same amount
22
Q

Alcohol absorption in greated detail?

A
  • Alcohol absorption: alcohol moves by passive diffusion across membranes from higher concentration (the GI tract) to lower concentration (the blood)
  • The greater the concentration of alcohol consumed, the more rapid the movement
  • Food in the stomach slows absorption
23
Q

How does gender affect alcohol absorption?

A
  • Gender differences not just due to differences in body size
  • Alcohol dehydrogenase in gastric fluid is about 60% more active in men than in women, leaving a higher concentration of alcohol that will be absorbed more rapidly in women
  • Aspirin inhibits gastic alcohol dehydrogenase in both genders, but to a greater extent in women than in men
  • Ethanol moves by passive diffusion from the higher concentration in the blood to all tissues and fluid compartments
  • The same amount of alcohol is more concentrated in the averae woman than in the averae man because her fluid volume is much smaller